Effects of Vitamin D Supplementation during the Induction and Progression of Osteoarthritis in a Rat Model

المؤلفون المشاركون

Ortiz-Navarrete, Vianney
Castillo, E. C.
Hernandez-Cueto, M. A.
Vega-Lopez, M. A.
Lavalle, C.
Kouri, J. B.

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-10-14

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

Epidemiological studies correlate low levels of vitamin D with the osteoarthritis (OA) progression.

Cytokines and metalloproteases play a major role in OA promoting the inflammation and degradation of the cartilage and can be induced through the Toll-like receptor (TLR) pathway.

The aim of this study was to evaluate the protective effect of vitamin D supplementation on the development of osteoarthritis (OA) through examining the genetic regulation of TLRs, cytokines, and metalloproteases in chondrocytes as well as the wideness of cartilage in rats with OA.

Our results demonstrate that the signaling through TLR-4 is a proinflammatory mechanism in osteoarthritis that drives the upregulation of MMP-3, IL-1β, and TNF-α gene expression, leading to cartilage degradation and inflammation.

Vitamin D supplementation had a protective effect during the onset but not during the chronic stage of OA in the rat model.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Castillo, E. C.& Hernandez-Cueto, M. A.& Vega-Lopez, M. A.& Lavalle, C.& Kouri, J. B.& Ortiz-Navarrete, Vianney. 2012. Effects of Vitamin D Supplementation during the Induction and Progression of Osteoarthritis in a Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992060

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Castillo, E. C.…[et al.]. Effects of Vitamin D Supplementation during the Induction and Progression of Osteoarthritis in a Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-992060

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Castillo, E. C.& Hernandez-Cueto, M. A.& Vega-Lopez, M. A.& Lavalle, C.& Kouri, J. B.& Ortiz-Navarrete, Vianney. Effects of Vitamin D Supplementation during the Induction and Progression of Osteoarthritis in a Rat Model. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992060

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-992060