Effects of Vitamin D Supplementation during the Induction and Progression of Osteoarthritis in a Rat Model
Joint Authors
Ortiz-Navarrete, Vianney
Castillo, E. C.
Hernandez-Cueto, M. A.
Vega-Lopez, M. A.
Lavalle, C.
Kouri, J. B.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Epidemiological studies correlate low levels of vitamin D with the osteoarthritis (OA) progression.
Cytokines and metalloproteases play a major role in OA promoting the inflammation and degradation of the cartilage and can be induced through the Toll-like receptor (TLR) pathway.
The aim of this study was to evaluate the protective effect of vitamin D supplementation on the development of osteoarthritis (OA) through examining the genetic regulation of TLRs, cytokines, and metalloproteases in chondrocytes as well as the wideness of cartilage in rats with OA.
Our results demonstrate that the signaling through TLR-4 is a proinflammatory mechanism in osteoarthritis that drives the upregulation of MMP-3, IL-1β, and TNF-α gene expression, leading to cartilage degradation and inflammation.
Vitamin D supplementation had a protective effect during the onset but not during the chronic stage of OA in the rat model.
American Psychological Association (APA)
Castillo, E. C.& Hernandez-Cueto, M. A.& Vega-Lopez, M. A.& Lavalle, C.& Kouri, J. B.& Ortiz-Navarrete, Vianney. 2012. Effects of Vitamin D Supplementation during the Induction and Progression of Osteoarthritis in a Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992060
Modern Language Association (MLA)
Castillo, E. C.…[et al.]. Effects of Vitamin D Supplementation during the Induction and Progression of Osteoarthritis in a Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-992060
American Medical Association (AMA)
Castillo, E. C.& Hernandez-Cueto, M. A.& Vega-Lopez, M. A.& Lavalle, C.& Kouri, J. B.& Ortiz-Navarrete, Vianney. Effects of Vitamin D Supplementation during the Induction and Progression of Osteoarthritis in a Rat Model. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992060
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992060