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Protection of Trigonelline on Experimental Diabetic Peripheral Neuropathy
المؤلفون المشاركون
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-06
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The mechanisms leading to diabetic peripheral neuropathy are complex and there is no effective drug to treat it.
As an active component of several traditional Chinese medicines, trigonelline has beneficial effects on diabetes with hyperlipidemia.
The protective effects and the mechanism of trigonelline on diabetic peripheral neuropathy were evaluated in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats.
Rats were divided into four groups at the end of week 2: control, diabetes, diabetes + trigonelline (40 mg/kg), and diabetes + sitagliptin (4 mg/kg).
After 48-week treatment, technologies of nerve conduction, cold and hot immersion test, transmission electron microscopy, real-time PCR, and Western blotting were applied.
Serum glucose, serum insulin, insulin sensitivity index, lipid parameters, body weight, sciatic nerve conduction velocity, nociception, glucagon-like peptide-1 receptor mRNA and protein, total and phosphorylated p38 mitogen-activated protein kinases protein expression, malonaldehyde content, and superoxide dismutase activity were altered in diabetic rats, and were near control levels treated with trigonelline.
Slight micropathological changes existed in sciatic nerve of trigonelline-treated diabetic rats.
These findings suggest that trigonelline has beneficial effects for diabetic peripheral neuropathy through glucagon-like peptide-1 receptor/p38 mitogen-activated protein kinases signaling pathway, nerve conduction velocity, antioxidant enzyme activity, improving micropathological changes of sciatic nerve and decreasing lipid peroxidation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Ji-Yin& Zhou, Shi-Wen. 2012. Protection of Trigonelline on Experimental Diabetic Peripheral Neuropathy. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992072
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Ji-Yin& Zhou, Shi-Wen. Protection of Trigonelline on Experimental Diabetic Peripheral Neuropathy. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992072
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Ji-Yin& Zhou, Shi-Wen. Protection of Trigonelline on Experimental Diabetic Peripheral Neuropathy. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992072
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992072
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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