![](/images/graphics-bg.png)
Protection of Trigonelline on Experimental Diabetic Peripheral Neuropathy
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The mechanisms leading to diabetic peripheral neuropathy are complex and there is no effective drug to treat it.
As an active component of several traditional Chinese medicines, trigonelline has beneficial effects on diabetes with hyperlipidemia.
The protective effects and the mechanism of trigonelline on diabetic peripheral neuropathy were evaluated in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats.
Rats were divided into four groups at the end of week 2: control, diabetes, diabetes + trigonelline (40 mg/kg), and diabetes + sitagliptin (4 mg/kg).
After 48-week treatment, technologies of nerve conduction, cold and hot immersion test, transmission electron microscopy, real-time PCR, and Western blotting were applied.
Serum glucose, serum insulin, insulin sensitivity index, lipid parameters, body weight, sciatic nerve conduction velocity, nociception, glucagon-like peptide-1 receptor mRNA and protein, total and phosphorylated p38 mitogen-activated protein kinases protein expression, malonaldehyde content, and superoxide dismutase activity were altered in diabetic rats, and were near control levels treated with trigonelline.
Slight micropathological changes existed in sciatic nerve of trigonelline-treated diabetic rats.
These findings suggest that trigonelline has beneficial effects for diabetic peripheral neuropathy through glucagon-like peptide-1 receptor/p38 mitogen-activated protein kinases signaling pathway, nerve conduction velocity, antioxidant enzyme activity, improving micropathological changes of sciatic nerve and decreasing lipid peroxidation.
American Psychological Association (APA)
Zhou, Ji-Yin& Zhou, Shi-Wen. 2012. Protection of Trigonelline on Experimental Diabetic Peripheral Neuropathy. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992072
Modern Language Association (MLA)
Zhou, Ji-Yin& Zhou, Shi-Wen. Protection of Trigonelline on Experimental Diabetic Peripheral Neuropathy. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992072
American Medical Association (AMA)
Zhou, Ji-Yin& Zhou, Shi-Wen. Protection of Trigonelline on Experimental Diabetic Peripheral Neuropathy. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992072
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992072