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Myrrh Inhibits LPS-Induced Inflammatory Response and Protects from Cecal Ligation and Puncture-Induced Sepsis
المؤلفون المشاركون
Kim, Min-Sun
Bae, Gi-Sang
Park, Kyoung-Chel
Koo, Bon Soon
Kim, Byung-Jin
Lee, Hye-Jin
Seo, Sang-Wan
Shin, Yong Kook
Jung, Won-Seok
Cho, Jung-Hee
Kim, Youn-Chul
Kim, Tae-Hyeon
Song, Ho-Joon
Park, Sung-Joo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Myrrh has been used as an antibacterial and anti-inflammatory agent.
However, effect of myrrh on peritoneal macrophages and clinically relevant models of septic shock, such as cecal ligation and puncture (CLP), is not well understood.
Here, we investigated the inhibitory effect and mechanism(s) of myrrh on inflammatory responses.
Myrrh inhibited LPS-induced productions of inflammatory mediators such as nitric oxide, prostaglandin E2, and tumor necrosis factor-α but not of interleukin (IL)-1β and IL-6 in peritoneal macrophages.
In addition, Myrrh inhibited LPS-induced activation of c-jun NH2-terminal kinase (JNK) but not of extracellular signal-regulated kinase (ERK), p38, and nuclear factor-κB.
Administration of Myrrh reduced the CLP-induced mortality and bacterial counts and inhibited inflammatory mediators.
Furthermore, administration of Myrrh attenuated CLP-induced liver damages, which were mainly evidenced by decreased infiltration of leukocytes and aspartate aminotransferase/alanine aminotransferase level.
Taken together, these results provide the evidence for the anti-inflammatory and antibacterial potential of Myrrh in sepsis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Min-Sun& Bae, Gi-Sang& Park, Kyoung-Chel& Koo, Bon Soon& Kim, Byung-Jin& Lee, Hye-Jin…[et al.]. 2011. Myrrh Inhibits LPS-Induced Inflammatory Response and Protects from Cecal Ligation and Puncture-Induced Sepsis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992163
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Min-Sun…[et al.]. Myrrh Inhibits LPS-Induced Inflammatory Response and Protects from Cecal Ligation and Puncture-Induced Sepsis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-992163
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Min-Sun& Bae, Gi-Sang& Park, Kyoung-Chel& Koo, Bon Soon& Kim, Byung-Jin& Lee, Hye-Jin…[et al.]. Myrrh Inhibits LPS-Induced Inflammatory Response and Protects from Cecal Ligation and Puncture-Induced Sepsis. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992163
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992163
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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