Myrrh Inhibits LPS-Induced Inflammatory Response and Protects from Cecal Ligation and Puncture-Induced Sepsis
Joint Authors
Kim, Min-Sun
Bae, Gi-Sang
Park, Kyoung-Chel
Koo, Bon Soon
Kim, Byung-Jin
Lee, Hye-Jin
Seo, Sang-Wan
Shin, Yong Kook
Jung, Won-Seok
Cho, Jung-Hee
Kim, Youn-Chul
Kim, Tae-Hyeon
Song, Ho-Joon
Park, Sung-Joo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Myrrh has been used as an antibacterial and anti-inflammatory agent.
However, effect of myrrh on peritoneal macrophages and clinically relevant models of septic shock, such as cecal ligation and puncture (CLP), is not well understood.
Here, we investigated the inhibitory effect and mechanism(s) of myrrh on inflammatory responses.
Myrrh inhibited LPS-induced productions of inflammatory mediators such as nitric oxide, prostaglandin E2, and tumor necrosis factor-α but not of interleukin (IL)-1β and IL-6 in peritoneal macrophages.
In addition, Myrrh inhibited LPS-induced activation of c-jun NH2-terminal kinase (JNK) but not of extracellular signal-regulated kinase (ERK), p38, and nuclear factor-κB.
Administration of Myrrh reduced the CLP-induced mortality and bacterial counts and inhibited inflammatory mediators.
Furthermore, administration of Myrrh attenuated CLP-induced liver damages, which were mainly evidenced by decreased infiltration of leukocytes and aspartate aminotransferase/alanine aminotransferase level.
Taken together, these results provide the evidence for the anti-inflammatory and antibacterial potential of Myrrh in sepsis.
American Psychological Association (APA)
Kim, Min-Sun& Bae, Gi-Sang& Park, Kyoung-Chel& Koo, Bon Soon& Kim, Byung-Jin& Lee, Hye-Jin…[et al.]. 2011. Myrrh Inhibits LPS-Induced Inflammatory Response and Protects from Cecal Ligation and Puncture-Induced Sepsis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992163
Modern Language Association (MLA)
Kim, Min-Sun…[et al.]. Myrrh Inhibits LPS-Induced Inflammatory Response and Protects from Cecal Ligation and Puncture-Induced Sepsis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-992163
American Medical Association (AMA)
Kim, Min-Sun& Bae, Gi-Sang& Park, Kyoung-Chel& Koo, Bon Soon& Kim, Byung-Jin& Lee, Hye-Jin…[et al.]. Myrrh Inhibits LPS-Induced Inflammatory Response and Protects from Cecal Ligation and Puncture-Induced Sepsis. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992163