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Intestinal, Airway, and Cardiovascular Relaxant Activities of Thymoquinone
المؤلفون المشاركون
Ghayur, Muhammad Nabeel
Gilani, Anwarul Hassan
Janssen, Luke L.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-18
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Thymoquinone (TQ) is a bioactive component found in many medicinal herbs.
In this study, we report the smooth and cardiac muscle relaxant activities of this compound.
TQ concentration dependently suppressed spontaneously contracting rabbit jejunum while also relaxed high K+-(80 mM) induced contractions in jejunum and guinea-pig ileum, indicating activity at voltage-operated Ca++ channels (VOCC).
Further, TQ displaced Ca++ concentration-response curves, obtained in a Ca++-free environment, to the right, showing blockade of VOCC.
Similar activity was observed with verapamil, a standard VOCC blocker.
TQ also exhibited nonadrenergic relaxation of agonist-induced contractions in guinea-pig trachea.
When tested in fluo-4-loaded mouse lung slices, TQ inhibited ACh-induced airway narrowing and Ca++ signalling in airway smooth muscle cells.
In endothelium-intact and endothelium-denuded rat aorta, TQ inhibited high K+-induced contractions at significantly lower concentrations than phenylephrine-(PE-) (1 microM) induced contractions.
Relaxation of PE-induced contractions was resistant to blockade by L-NAME and atropine.
In guinea-pig atria, TQ showed noncholinergic relaxation of atrial force and rate of contractions.
These data suggest smooth and cardiac muscle relaxant activity of TQ possibly mediated, in part, via blockade of VOCC.
The results also justify the use of TQ containing plants in related health disorders like colic, diarrhoea, cough, and asthma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ghayur, Muhammad Nabeel& Gilani, Anwarul Hassan& Janssen, Luke L.. 2012. Intestinal, Airway, and Cardiovascular Relaxant Activities of Thymoquinone. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-992184
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghayur, Muhammad Nabeel…[et al.]. Intestinal, Airway, and Cardiovascular Relaxant Activities of Thymoquinone. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-992184
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ghayur, Muhammad Nabeel& Gilani, Anwarul Hassan& Janssen, Luke L.. Intestinal, Airway, and Cardiovascular Relaxant Activities of Thymoquinone. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-992184
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992184
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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