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Intestinal, Airway, and Cardiovascular Relaxant Activities of Thymoquinone
Joint Authors
Ghayur, Muhammad Nabeel
Gilani, Anwarul Hassan
Janssen, Luke L.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Thymoquinone (TQ) is a bioactive component found in many medicinal herbs.
In this study, we report the smooth and cardiac muscle relaxant activities of this compound.
TQ concentration dependently suppressed spontaneously contracting rabbit jejunum while also relaxed high K+-(80 mM) induced contractions in jejunum and guinea-pig ileum, indicating activity at voltage-operated Ca++ channels (VOCC).
Further, TQ displaced Ca++ concentration-response curves, obtained in a Ca++-free environment, to the right, showing blockade of VOCC.
Similar activity was observed with verapamil, a standard VOCC blocker.
TQ also exhibited nonadrenergic relaxation of agonist-induced contractions in guinea-pig trachea.
When tested in fluo-4-loaded mouse lung slices, TQ inhibited ACh-induced airway narrowing and Ca++ signalling in airway smooth muscle cells.
In endothelium-intact and endothelium-denuded rat aorta, TQ inhibited high K+-induced contractions at significantly lower concentrations than phenylephrine-(PE-) (1 microM) induced contractions.
Relaxation of PE-induced contractions was resistant to blockade by L-NAME and atropine.
In guinea-pig atria, TQ showed noncholinergic relaxation of atrial force and rate of contractions.
These data suggest smooth and cardiac muscle relaxant activity of TQ possibly mediated, in part, via blockade of VOCC.
The results also justify the use of TQ containing plants in related health disorders like colic, diarrhoea, cough, and asthma.
American Psychological Association (APA)
Ghayur, Muhammad Nabeel& Gilani, Anwarul Hassan& Janssen, Luke L.. 2012. Intestinal, Airway, and Cardiovascular Relaxant Activities of Thymoquinone. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-992184
Modern Language Association (MLA)
Ghayur, Muhammad Nabeel…[et al.]. Intestinal, Airway, and Cardiovascular Relaxant Activities of Thymoquinone. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-992184
American Medical Association (AMA)
Ghayur, Muhammad Nabeel& Gilani, Anwarul Hassan& Janssen, Luke L.. Intestinal, Airway, and Cardiovascular Relaxant Activities of Thymoquinone. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-992184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992184