Effects of Sangu Decoction on Osteoclast Activity in a Rat Model of Breast Cancer Bone Metastasis
المؤلفون المشاركون
Deng, Bo
Jia, Li-qun
Tan, Huang-ying
Yao, Xuan
Gao, Fu-yun
Pan, Lin
Cui, Jian
Xiang, Qing
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-06
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Bone metastasis (BM) is a major clinical problem for which current treatments lack full efficacy.
The Traditional Chinese Medicine (TCM) Sangu Decoction (SGD) has been widely used to treat BM in China.
However, no in vivo experiments to date have investigated the effects of TCM on osteoclast activity in BM.
In this study, the protective effect and probable mechanism of SGD were evaluated.
The model was established using the breast cancer MRMT-1 cells injected into the tibia of rat.
SGD was administrated, compared with Zoledronic acid as a positive control.
The development of the bone tumor and osteoclast activity was monitored by radiological analysis.
TRAP stain was used to identify osteoclasts quantity and activity.
TRAP-5b in serum or bone tumor and TRAP mRNA were also quantified.
Radiological examination showed that SGD inhibited tumor proliferation and preserved the cortical and trabecular bone structure.
In addition, a dramatic reduction of TRAP positive osteoclasts was observed and TRAP-5b levels in serum and bone tumor decreased significantly.
It also reduced the mRNA expression of TRAP.
The results indicated that SGD exerted potent antiosteoclast property that could be directly related to its TRAP inhibited activity.
In addition it prevented bone tumor proliferation in BM model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Deng, Bo& Jia, Li-qun& Tan, Huang-ying& Yao, Xuan& Gao, Fu-yun& Pan, Lin…[et al.]. 2012. Effects of Sangu Decoction on Osteoclast Activity in a Rat Model of Breast Cancer Bone Metastasis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992234
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Deng, Bo…[et al.]. Effects of Sangu Decoction on Osteoclast Activity in a Rat Model of Breast Cancer Bone Metastasis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992234
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Deng, Bo& Jia, Li-qun& Tan, Huang-ying& Yao, Xuan& Gao, Fu-yun& Pan, Lin…[et al.]. Effects of Sangu Decoction on Osteoclast Activity in a Rat Model of Breast Cancer Bone Metastasis. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992234
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992234
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر