Effects of Sangu Decoction on Osteoclast Activity in a Rat Model of Breast Cancer Bone Metastasis
Joint Authors
Deng, Bo
Jia, Li-qun
Tan, Huang-ying
Yao, Xuan
Gao, Fu-yun
Pan, Lin
Cui, Jian
Xiang, Qing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Bone metastasis (BM) is a major clinical problem for which current treatments lack full efficacy.
The Traditional Chinese Medicine (TCM) Sangu Decoction (SGD) has been widely used to treat BM in China.
However, no in vivo experiments to date have investigated the effects of TCM on osteoclast activity in BM.
In this study, the protective effect and probable mechanism of SGD were evaluated.
The model was established using the breast cancer MRMT-1 cells injected into the tibia of rat.
SGD was administrated, compared with Zoledronic acid as a positive control.
The development of the bone tumor and osteoclast activity was monitored by radiological analysis.
TRAP stain was used to identify osteoclasts quantity and activity.
TRAP-5b in serum or bone tumor and TRAP mRNA were also quantified.
Radiological examination showed that SGD inhibited tumor proliferation and preserved the cortical and trabecular bone structure.
In addition, a dramatic reduction of TRAP positive osteoclasts was observed and TRAP-5b levels in serum and bone tumor decreased significantly.
It also reduced the mRNA expression of TRAP.
The results indicated that SGD exerted potent antiosteoclast property that could be directly related to its TRAP inhibited activity.
In addition it prevented bone tumor proliferation in BM model.
American Psychological Association (APA)
Deng, Bo& Jia, Li-qun& Tan, Huang-ying& Yao, Xuan& Gao, Fu-yun& Pan, Lin…[et al.]. 2012. Effects of Sangu Decoction on Osteoclast Activity in a Rat Model of Breast Cancer Bone Metastasis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992234
Modern Language Association (MLA)
Deng, Bo…[et al.]. Effects of Sangu Decoction on Osteoclast Activity in a Rat Model of Breast Cancer Bone Metastasis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992234
American Medical Association (AMA)
Deng, Bo& Jia, Li-qun& Tan, Huang-ying& Yao, Xuan& Gao, Fu-yun& Pan, Lin…[et al.]. Effects of Sangu Decoction on Osteoclast Activity in a Rat Model of Breast Cancer Bone Metastasis. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992234