Epicatechin Used in the Treatment of Intestinal Inflammatory Disease: An Analysis by Experimental Models
المؤلفون المشاركون
Vasconcelos, Paulo César de Paula
Seito, Leonardo Noboru
Di Stasi, Luiz Cláudio
Akiko Hiruma-Lima, Clélia
Pellizzon, Cláudia Helena
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
This study was pathway of (−)-epicatechin (EC) in the prevention and treatment of intestine inflammation in acute and chronic rat models.
Methods.
Intestine inflammation was induced in rats using TNBS.
The morphological, inflammatory, immunohistochemical, and immunoblotting characteristics of colon samples were examined.
The effects of EC were evaluated in an acute model at doses of 5, 10, 25, and 50 mg/kg by gavage for 5 days.
The chronic colitis model was induced 1st day, and treated for 21 days.
For the colitis relapse model, the induction was repeated on 14th.
Results.
EC10 and EC50 effectively reduced the lesion size, as assessed macroscopically; and confirmed by microscopy for EC10.
The glutathione levels were higher in EC10 group but decreased COX-2 expression and increased cell proliferation (PC) were observed, indicating an anti-inflammatory activity and a proliferation-stimulating effect.
In the chronic colitis model, EC10 showed lower macroscopic and microscopic lesion scores and increase in glutathione levels.
As in the acute model, a decrease in COX-2 expression and an increase in PC in EC10, the chronic model this increase maybe by the pathway EGF expression.
Conclusion.
These results confirm the activity of EC as an antioxidant that reduces of the lesion and that has the potential to stimulate tissue healing, indicating useful for preventing and treating intestine inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vasconcelos, Paulo César de Paula& Seito, Leonardo Noboru& Di Stasi, Luiz Cláudio& Akiko Hiruma-Lima, Clélia& Pellizzon, Cláudia Helena. 2012. Epicatechin Used in the Treatment of Intestinal Inflammatory Disease: An Analysis by Experimental Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992366
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vasconcelos, Paulo César de Paula…[et al.]. Epicatechin Used in the Treatment of Intestinal Inflammatory Disease: An Analysis by Experimental Models. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-992366
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vasconcelos, Paulo César de Paula& Seito, Leonardo Noboru& Di Stasi, Luiz Cláudio& Akiko Hiruma-Lima, Clélia& Pellizzon, Cláudia Helena. Epicatechin Used in the Treatment of Intestinal Inflammatory Disease: An Analysis by Experimental Models. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992366
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992366
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر