Epicatechin Used in the Treatment of Intestinal Inflammatory Disease: An Analysis by Experimental Models
Joint Authors
Vasconcelos, Paulo César de Paula
Seito, Leonardo Noboru
Di Stasi, Luiz Cláudio
Akiko Hiruma-Lima, Clélia
Pellizzon, Cláudia Helena
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study was pathway of (−)-epicatechin (EC) in the prevention and treatment of intestine inflammation in acute and chronic rat models.
Methods.
Intestine inflammation was induced in rats using TNBS.
The morphological, inflammatory, immunohistochemical, and immunoblotting characteristics of colon samples were examined.
The effects of EC were evaluated in an acute model at doses of 5, 10, 25, and 50 mg/kg by gavage for 5 days.
The chronic colitis model was induced 1st day, and treated for 21 days.
For the colitis relapse model, the induction was repeated on 14th.
Results.
EC10 and EC50 effectively reduced the lesion size, as assessed macroscopically; and confirmed by microscopy for EC10.
The glutathione levels were higher in EC10 group but decreased COX-2 expression and increased cell proliferation (PC) were observed, indicating an anti-inflammatory activity and a proliferation-stimulating effect.
In the chronic colitis model, EC10 showed lower macroscopic and microscopic lesion scores and increase in glutathione levels.
As in the acute model, a decrease in COX-2 expression and an increase in PC in EC10, the chronic model this increase maybe by the pathway EGF expression.
Conclusion.
These results confirm the activity of EC as an antioxidant that reduces of the lesion and that has the potential to stimulate tissue healing, indicating useful for preventing and treating intestine inflammation.
American Psychological Association (APA)
Vasconcelos, Paulo César de Paula& Seito, Leonardo Noboru& Di Stasi, Luiz Cláudio& Akiko Hiruma-Lima, Clélia& Pellizzon, Cláudia Helena. 2012. Epicatechin Used in the Treatment of Intestinal Inflammatory Disease: An Analysis by Experimental Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992366
Modern Language Association (MLA)
Vasconcelos, Paulo César de Paula…[et al.]. Epicatechin Used in the Treatment of Intestinal Inflammatory Disease: An Analysis by Experimental Models. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-992366
American Medical Association (AMA)
Vasconcelos, Paulo César de Paula& Seito, Leonardo Noboru& Di Stasi, Luiz Cláudio& Akiko Hiruma-Lima, Clélia& Pellizzon, Cláudia Helena. Epicatechin Used in the Treatment of Intestinal Inflammatory Disease: An Analysis by Experimental Models. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992366
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992366