Inhibitory Effects of Glycyrrhetinic Acid on DNA Polymerase and Inflammatory Activities
المؤلفون المشاركون
Ishida, Tsukasa
Mizushina, Yoshiyuki
Yagi, Saori
Irino, Yasuhiro
Nishiumi, Shin
Miki, Ikuya
Kondo, Yasuyuki
Mizuno, Shigeto
Yoshida, Hiromi
Azuma, Takeshi
Yoshida, Masaru
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-07-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
We investigated the inhibitory effect of three glycyrrhizin derivatives, such as Glycyrrhizin (compound 1), dipotassium glycyrrhizate (compound 2) and glycyrrhetinic acid (compound 3), on the activity of mammalian pols.
Among these derivatives, compound 3 was the strongest inhibitor of mammalian pols α, β, κ, and λ, which belong to the B, A, Y, and X families of pols, respectively, whereas compounds 1 and 2 showed moderate inhibition.
Among the these derivatives tested, compound 3 displayed strongest suppression of the production of tumor necrosis factor-α (TNF-α) induced by lipopolysaccharide (LPS) in a cell-culture system using mouse macrophages RAW264.7 and peritoneal macrophages derived from mice.
Moreover, compound 3 was found to inhibit the action of nuclear factor-κB (NF-κB) in engineered human embryonic kidney (HEK) 293 cells.
In addition, compound 3 caused greater reduction of 12-O-tetradecanoylphorbol-13-acetate-(TPA-) induced acute inflammation in mouse ear than compounds 1 and 2.
In conclusion, this study has identified compound 3, which is the aglycone of compounds 1 and 2, as a promising anti-inflammatory candidate based on mammalian pol inhibition.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ishida, Tsukasa& Mizushina, Yoshiyuki& Yagi, Saori& Irino, Yasuhiro& Nishiumi, Shin& Miki, Ikuya…[et al.]. 2011. Inhibitory Effects of Glycyrrhetinic Acid on DNA Polymerase and Inflammatory Activities. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992501
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ishida, Tsukasa…[et al.]. Inhibitory Effects of Glycyrrhetinic Acid on DNA Polymerase and Inflammatory Activities. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-992501
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ishida, Tsukasa& Mizushina, Yoshiyuki& Yagi, Saori& Irino, Yasuhiro& Nishiumi, Shin& Miki, Ikuya…[et al.]. Inhibitory Effects of Glycyrrhetinic Acid on DNA Polymerase and Inflammatory Activities. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992501
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992501
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر