Inhibitory Effects of Glycyrrhetinic Acid on DNA Polymerase and Inflammatory Activities
Joint Authors
Ishida, Tsukasa
Mizushina, Yoshiyuki
Yagi, Saori
Irino, Yasuhiro
Nishiumi, Shin
Miki, Ikuya
Kondo, Yasuyuki
Mizuno, Shigeto
Yoshida, Hiromi
Azuma, Takeshi
Yoshida, Masaru
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We investigated the inhibitory effect of three glycyrrhizin derivatives, such as Glycyrrhizin (compound 1), dipotassium glycyrrhizate (compound 2) and glycyrrhetinic acid (compound 3), on the activity of mammalian pols.
Among these derivatives, compound 3 was the strongest inhibitor of mammalian pols α, β, κ, and λ, which belong to the B, A, Y, and X families of pols, respectively, whereas compounds 1 and 2 showed moderate inhibition.
Among the these derivatives tested, compound 3 displayed strongest suppression of the production of tumor necrosis factor-α (TNF-α) induced by lipopolysaccharide (LPS) in a cell-culture system using mouse macrophages RAW264.7 and peritoneal macrophages derived from mice.
Moreover, compound 3 was found to inhibit the action of nuclear factor-κB (NF-κB) in engineered human embryonic kidney (HEK) 293 cells.
In addition, compound 3 caused greater reduction of 12-O-tetradecanoylphorbol-13-acetate-(TPA-) induced acute inflammation in mouse ear than compounds 1 and 2.
In conclusion, this study has identified compound 3, which is the aglycone of compounds 1 and 2, as a promising anti-inflammatory candidate based on mammalian pol inhibition.
American Psychological Association (APA)
Ishida, Tsukasa& Mizushina, Yoshiyuki& Yagi, Saori& Irino, Yasuhiro& Nishiumi, Shin& Miki, Ikuya…[et al.]. 2011. Inhibitory Effects of Glycyrrhetinic Acid on DNA Polymerase and Inflammatory Activities. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992501
Modern Language Association (MLA)
Ishida, Tsukasa…[et al.]. Inhibitory Effects of Glycyrrhetinic Acid on DNA Polymerase and Inflammatory Activities. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-992501
American Medical Association (AMA)
Ishida, Tsukasa& Mizushina, Yoshiyuki& Yagi, Saori& Irino, Yasuhiro& Nishiumi, Shin& Miki, Ikuya…[et al.]. Inhibitory Effects of Glycyrrhetinic Acid on DNA Polymerase and Inflammatory Activities. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992501
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992501