7α-Hydroxy-β-Sitosterol from Chisocheton tomentosus Induces Apoptosis via Dysregulation of Cellular BaxBcl-2 Ratio and Cell Cycle Arrest by Downregulating ERK12 Activation
المؤلفون المشاركون
Tasyriq, Mohammad
Najmuldeen, Ibrahim A.
In, Lionel L. A.
Mohamad, Khalit
Nagoor, Noor Hasima
Awang, Khalijah
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-11
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
In continuation of our interest towards the elucidation of apoptotic pathways of cytotoxic phytocompounds, we have embarked upon a study on the anticancer effects of 7α-hydroxy-β-sitosterol (CT1), a rare natural phytosterol oxide isolated from Chisocheton tomentosus.
CT1 was found to be cytotoxic on three different human tumor cell lines with minimal effects on normal cell controls, where cell viability levels were maintained ≥80% upon treatment.
Our results showed that cell death in MCF-7 breast tumor cells was achieved through the induction of apoptosis via downregulation of the ERK1/2 signaling pathway.
CT1 was also found to increase proapoptotic Bax protein levels, while decreasing anti-apoptotic Bcl-2 protein levels, suggesting the involvement of the intrinsic pathway.
Reduced levels of initiator procaspase-9 and executioner procaspase-3 were also observed following CT1 exposure, confirming the involvement of cytochrome c-mediated apoptosis via the mitochondrial pathway.
These results demonstrated the cytotoxic and apoptotic ability of 7α-hydroxy-β-sitosterol and suggest its potential anti-cancer use particularly on breast adenocarcinoma cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tasyriq, Mohammad& Najmuldeen, Ibrahim A.& In, Lionel L. A.& Mohamad, Khalit& Awang, Khalijah& Nagoor, Noor Hasima. 2012. 7α-Hydroxy-β-Sitosterol from Chisocheton tomentosus Induces Apoptosis via Dysregulation of Cellular BaxBcl-2 Ratio and Cell Cycle Arrest by Downregulating ERK12 Activation. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992625
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tasyriq, Mohammad…[et al.]. 7α-Hydroxy-β-Sitosterol from Chisocheton tomentosus Induces Apoptosis via Dysregulation of Cellular BaxBcl-2 Ratio and Cell Cycle Arrest by Downregulating ERK12 Activation. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-992625
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tasyriq, Mohammad& Najmuldeen, Ibrahim A.& In, Lionel L. A.& Mohamad, Khalit& Awang, Khalijah& Nagoor, Noor Hasima. 7α-Hydroxy-β-Sitosterol from Chisocheton tomentosus Induces Apoptosis via Dysregulation of Cellular BaxBcl-2 Ratio and Cell Cycle Arrest by Downregulating ERK12 Activation. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992625
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992625
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر