The Components of Flemingia macrophylla Attenuate Amyloid β-Protein Accumulation by Regulating Amyloid β-Protein Metabolic Pathway
المؤلفون المشاركون
Lin, Yun-Lian
Tsay, Huey-Jen
Liao, Yung-Feng
Wu, Mine-Fong
Wang, Chuen-Neu
Shiao, Young-Ji
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Flemingia macrophylla (Leguminosae) is a popular traditional remedy used in Taiwan as anti-inflammatory, promoting blood circulation and antidiabetes agent.
Recent study also suggested its neuroprotective activity against Alzheimer's disease.
Therefore, the effects of F.
macrophylla on Aβ production and degradation were studied.
The effect of F.
macrophylla on Aβ metabolism was detected using the cultured mouse neuroblastoma cells N2a transfected with human Swedish mutant APP (swAPP-N2a cells).
The effects on Aβ degradation were evaluated on a cell-free system.
An ELISA assay was applied to detect the level of Aβ1-40 and Aβ1-42.
Western blots assay was employed to measure the levels of soluble amyloid precursor protein and insulin degrading enzyme (IDE).
Three fractions of F.
macrophylla modified Aβ accumulation by both inhibiting β-secretase and activating IDE.
Three flavonoids modified Aβ accumulation by activating IDE.
The activated IDE pool by the flavonoids was distinctly regulated by bacitracin (an IDE inhibitor).
Furthermore, flavonoid 94-18-13 also modulates Aβ accumulation by enhancing IDE expression.
In conclusion, the components of F.
macrophylla possess the potential for developing new therapeutic drugs for Alzheimer's disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Yun-Lian& Tsay, Huey-Jen& Liao, Yung-Feng& Wu, Mine-Fong& Wang, Chuen-Neu& Shiao, Young-Ji. 2012. The Components of Flemingia macrophylla Attenuate Amyloid β-Protein Accumulation by Regulating Amyloid β-Protein Metabolic Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992651
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Yun-Lian…[et al.]. The Components of Flemingia macrophylla Attenuate Amyloid β-Protein Accumulation by Regulating Amyloid β-Protein Metabolic Pathway. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-992651
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Yun-Lian& Tsay, Huey-Jen& Liao, Yung-Feng& Wu, Mine-Fong& Wang, Chuen-Neu& Shiao, Young-Ji. The Components of Flemingia macrophylla Attenuate Amyloid β-Protein Accumulation by Regulating Amyloid β-Protein Metabolic Pathway. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992651
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992651
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر