The Components of Flemingia macrophylla Attenuate Amyloid β-Protein Accumulation by Regulating Amyloid β-Protein Metabolic Pathway
Joint Authors
Lin, Yun-Lian
Tsay, Huey-Jen
Liao, Yung-Feng
Wu, Mine-Fong
Wang, Chuen-Neu
Shiao, Young-Ji
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Flemingia macrophylla (Leguminosae) is a popular traditional remedy used in Taiwan as anti-inflammatory, promoting blood circulation and antidiabetes agent.
Recent study also suggested its neuroprotective activity against Alzheimer's disease.
Therefore, the effects of F.
macrophylla on Aβ production and degradation were studied.
The effect of F.
macrophylla on Aβ metabolism was detected using the cultured mouse neuroblastoma cells N2a transfected with human Swedish mutant APP (swAPP-N2a cells).
The effects on Aβ degradation were evaluated on a cell-free system.
An ELISA assay was applied to detect the level of Aβ1-40 and Aβ1-42.
Western blots assay was employed to measure the levels of soluble amyloid precursor protein and insulin degrading enzyme (IDE).
Three fractions of F.
macrophylla modified Aβ accumulation by both inhibiting β-secretase and activating IDE.
Three flavonoids modified Aβ accumulation by activating IDE.
The activated IDE pool by the flavonoids was distinctly regulated by bacitracin (an IDE inhibitor).
Furthermore, flavonoid 94-18-13 also modulates Aβ accumulation by enhancing IDE expression.
In conclusion, the components of F.
macrophylla possess the potential for developing new therapeutic drugs for Alzheimer's disease.
American Psychological Association (APA)
Lin, Yun-Lian& Tsay, Huey-Jen& Liao, Yung-Feng& Wu, Mine-Fong& Wang, Chuen-Neu& Shiao, Young-Ji. 2012. The Components of Flemingia macrophylla Attenuate Amyloid β-Protein Accumulation by Regulating Amyloid β-Protein Metabolic Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992651
Modern Language Association (MLA)
Lin, Yun-Lian…[et al.]. The Components of Flemingia macrophylla Attenuate Amyloid β-Protein Accumulation by Regulating Amyloid β-Protein Metabolic Pathway. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-992651
American Medical Association (AMA)
Lin, Yun-Lian& Tsay, Huey-Jen& Liao, Yung-Feng& Wu, Mine-Fong& Wang, Chuen-Neu& Shiao, Young-Ji. The Components of Flemingia macrophylla Attenuate Amyloid β-Protein Accumulation by Regulating Amyloid β-Protein Metabolic Pathway. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992651
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992651