Mechanisms of Edible Bird's Nest Extract-Induced Proliferation of Human Adipose-Derived Stem Cells

المؤلفون المشاركون

Roh, Kyung-Baeg
Lee, Jienny
Kim, Young-Soo
Park, Junho
Kim, Jang-Hyun
Lee, Jongsung
Park, Deokhoon

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-11-01

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الطب البشري

الملخص EN

Although edible bird's nest (EBN) has been shown to potentiate mitogenic responses, scientific evidence of its efficacy is still limited.

In addition, human adipose-derived stem cells (hADSCs) are increasingly accepted as a source for stem cell therapy.

Therefore, the aim of this study was to investigate the effects of the EBN extract (EBNE) on the proliferation of hADSCs and its action mechanisms.

We found that EBNE strongly promoted the proliferation of hADSCs.

In addition, EBNE-induced proliferation was found to be mediated through the production of IL-6 and VEGF, which was induced by activation of AP-1 and NF-κB.

Specially, we found that production of IL-6 and VEGF was induced by EBNE.

In addition, EBNE-induced production of IL-6 and VEGF was inhibited by PD98059 (a p44/42 MAPK inhibitor), SB203580 (a p38 MAPK inhibitor), and PDTC (a NF-κB inhibitor), but not SP600125 (a JNK inhibitor).

Similarly, EBNE-induced proliferation of hADSCs was also attenuated by PD98059, SB203580, and PDTC but not SP600125.

Taken together, these findings suggest that the EBNE-induced proliferation of hADSCs primarily occurs through increased expression of IL-6 and VEGF genes, which is mediated by the activation of NF-κB and AP-1 through p44/42 MAPK and p38 MAPK.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Roh, Kyung-Baeg& Lee, Jienny& Kim, Young-Soo& Park, Junho& Kim, Jang-Hyun& Lee, Jongsung…[et al.]. 2011. Mechanisms of Edible Bird's Nest Extract-Induced Proliferation of Human Adipose-Derived Stem Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992652

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Roh, Kyung-Baeg…[et al.]. Mechanisms of Edible Bird's Nest Extract-Induced Proliferation of Human Adipose-Derived Stem Cells. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-992652

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Roh, Kyung-Baeg& Lee, Jienny& Kim, Young-Soo& Park, Junho& Kim, Jang-Hyun& Lee, Jongsung…[et al.]. Mechanisms of Edible Bird's Nest Extract-Induced Proliferation of Human Adipose-Derived Stem Cells. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992652

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-992652