Mechanisms of Edible Bird's Nest Extract-Induced Proliferation of Human Adipose-Derived Stem Cells
Joint Authors
Roh, Kyung-Baeg
Lee, Jienny
Kim, Young-Soo
Park, Junho
Kim, Jang-Hyun
Lee, Jongsung
Park, Deokhoon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Although edible bird's nest (EBN) has been shown to potentiate mitogenic responses, scientific evidence of its efficacy is still limited.
In addition, human adipose-derived stem cells (hADSCs) are increasingly accepted as a source for stem cell therapy.
Therefore, the aim of this study was to investigate the effects of the EBN extract (EBNE) on the proliferation of hADSCs and its action mechanisms.
We found that EBNE strongly promoted the proliferation of hADSCs.
In addition, EBNE-induced proliferation was found to be mediated through the production of IL-6 and VEGF, which was induced by activation of AP-1 and NF-κB.
Specially, we found that production of IL-6 and VEGF was induced by EBNE.
In addition, EBNE-induced production of IL-6 and VEGF was inhibited by PD98059 (a p44/42 MAPK inhibitor), SB203580 (a p38 MAPK inhibitor), and PDTC (a NF-κB inhibitor), but not SP600125 (a JNK inhibitor).
Similarly, EBNE-induced proliferation of hADSCs was also attenuated by PD98059, SB203580, and PDTC but not SP600125.
Taken together, these findings suggest that the EBNE-induced proliferation of hADSCs primarily occurs through increased expression of IL-6 and VEGF genes, which is mediated by the activation of NF-κB and AP-1 through p44/42 MAPK and p38 MAPK.
American Psychological Association (APA)
Roh, Kyung-Baeg& Lee, Jienny& Kim, Young-Soo& Park, Junho& Kim, Jang-Hyun& Lee, Jongsung…[et al.]. 2011. Mechanisms of Edible Bird's Nest Extract-Induced Proliferation of Human Adipose-Derived Stem Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992652
Modern Language Association (MLA)
Roh, Kyung-Baeg…[et al.]. Mechanisms of Edible Bird's Nest Extract-Induced Proliferation of Human Adipose-Derived Stem Cells. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-992652
American Medical Association (AMA)
Roh, Kyung-Baeg& Lee, Jienny& Kim, Young-Soo& Park, Junho& Kim, Jang-Hyun& Lee, Jongsung…[et al.]. Mechanisms of Edible Bird's Nest Extract-Induced Proliferation of Human Adipose-Derived Stem Cells. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992652
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992652