Mechanism by Sambucus nigra Extract Improves Bone Mineral Density in Experimental Diabetes
المؤلفون المشاركون
Bădulescu, Oana
Bădescu, Magda
Ciocoiu, Manuela
Badescu, Laurentiu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-13
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The effects of polyphenols extracted from Sambucus nigra fruit were studied in streptozotocin- (STZ-) induced hyperglycemic rats to evaluate its possible antioxidant, anti-inflammatory, antiglycosylation activity, and antiosteoporosis effects in diabetes.
DEXA bone mineral density tests were performed in order to determine bone mineral density (BMD), bone mineral content (BMC), and fat (%Fat) in control and diabetic animals, before and after polyphenol delivery.
As compared to the normoglycemic group, the rats treated with STZ (60 mg/kg body weight) revealed a significant malondialdehyde (MDA) increase, as an index of the lipid peroxidation level, by 69%, while the total antioxidant activity (TAS) dropped by 36%, with a consistently significant decrease (P<0.05) in the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX).
Also, the treatment of rats with STZ revealed a significant increase of IL-6, glycosylated haemoglobin (HbA1c), and osteopenia detected by DEXA bone mineral density tests.
The recorded results highlight a significant improvement (P<0.001) in the antioxidative capacity of the serum in diabetic rats treated with natural polyphenols, bringing back to normal the concentration of reduced glutathione (GSH), as well as an important decrease in the serum concentration of MDA, with improved osteoporosis status.
Knowing the effects of polyphenols could lead to the use of the polyphenolic extract of Sambucus nigra as a dietary supplement in diabetic osteoporosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Badescu, Laurentiu& Bădulescu, Oana& Bădescu, Magda& Ciocoiu, Manuela. 2012. Mechanism by Sambucus nigra Extract Improves Bone Mineral Density in Experimental Diabetes. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-992711
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Badescu, Laurentiu…[et al.]. Mechanism by Sambucus nigra Extract Improves Bone Mineral Density in Experimental Diabetes. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-992711
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Badescu, Laurentiu& Bădulescu, Oana& Bădescu, Magda& Ciocoiu, Manuela. Mechanism by Sambucus nigra Extract Improves Bone Mineral Density in Experimental Diabetes. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-992711
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992711
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر