Mechanism by Sambucus nigra Extract Improves Bone Mineral Density in Experimental Diabetes
Joint Authors
Bădulescu, Oana
Bădescu, Magda
Ciocoiu, Manuela
Badescu, Laurentiu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The effects of polyphenols extracted from Sambucus nigra fruit were studied in streptozotocin- (STZ-) induced hyperglycemic rats to evaluate its possible antioxidant, anti-inflammatory, antiglycosylation activity, and antiosteoporosis effects in diabetes.
DEXA bone mineral density tests were performed in order to determine bone mineral density (BMD), bone mineral content (BMC), and fat (%Fat) in control and diabetic animals, before and after polyphenol delivery.
As compared to the normoglycemic group, the rats treated with STZ (60 mg/kg body weight) revealed a significant malondialdehyde (MDA) increase, as an index of the lipid peroxidation level, by 69%, while the total antioxidant activity (TAS) dropped by 36%, with a consistently significant decrease (P<0.05) in the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX).
Also, the treatment of rats with STZ revealed a significant increase of IL-6, glycosylated haemoglobin (HbA1c), and osteopenia detected by DEXA bone mineral density tests.
The recorded results highlight a significant improvement (P<0.001) in the antioxidative capacity of the serum in diabetic rats treated with natural polyphenols, bringing back to normal the concentration of reduced glutathione (GSH), as well as an important decrease in the serum concentration of MDA, with improved osteoporosis status.
Knowing the effects of polyphenols could lead to the use of the polyphenolic extract of Sambucus nigra as a dietary supplement in diabetic osteoporosis.
American Psychological Association (APA)
Badescu, Laurentiu& Bădulescu, Oana& Bădescu, Magda& Ciocoiu, Manuela. 2012. Mechanism by Sambucus nigra Extract Improves Bone Mineral Density in Experimental Diabetes. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-992711
Modern Language Association (MLA)
Badescu, Laurentiu…[et al.]. Mechanism by Sambucus nigra Extract Improves Bone Mineral Density in Experimental Diabetes. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-992711
American Medical Association (AMA)
Badescu, Laurentiu& Bădulescu, Oana& Bădescu, Magda& Ciocoiu, Manuela. Mechanism by Sambucus nigra Extract Improves Bone Mineral Density in Experimental Diabetes. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-992711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992711