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Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy
المؤلفون المشاركون
Shen, Jiangang
Wang, Zhiyu
Wang, Neng
Chen, Jianping
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-12
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Molecular-targeted therapy has been developed for cancer chemoprevention and treatment.
Cancer cells have different metabolic properties from normal cells.
Normal cells mostly rely upon the process of mitochondrial oxidative phosphorylation to produce energy whereas cancer cells have developed an altered metabolism that allows them to sustain higher proliferation rates.
Cancer cells could predominantly produce energy by glycolysis even in the presence of oxygen.
This alternative metabolic characteristic is known as the “Warburg Effect.” Although the exact mechanisms underlying the Warburg effect are unclear, recent progress indicates that glycolytic pathway of cancer cells could be a critical target for drug discovery.
With a long history in cancer treatment, traditional Chinese medicine (TCM) is recognized as a valuable source for seeking bioactive anticancer compounds.
A great progress has been made to identify active compounds from herbal medicine targeting on glycolysis for cancer treatment.
Herein, we provide an overall picture of the current understanding of the molecular targets in the cancer glycolytic pathway and reviewed active compounds from Chinese herbal medicine with the potentials to inhibit the metabolic targets for cancer treatment.
Combination of TCM with conventional therapies will provide an attractive strategy for improving clinical outcome in cancer treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Zhiyu& Wang, Neng& Chen, Jianping& Shen, Jiangang. 2012. Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-992734
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Zhiyu…[et al.]. Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-992734
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Zhiyu& Wang, Neng& Chen, Jianping& Shen, Jiangang. Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-992734
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992734
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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