![](/images/graphics-bg.png)
Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy
Joint Authors
Shen, Jiangang
Wang, Zhiyu
Wang, Neng
Chen, Jianping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Molecular-targeted therapy has been developed for cancer chemoprevention and treatment.
Cancer cells have different metabolic properties from normal cells.
Normal cells mostly rely upon the process of mitochondrial oxidative phosphorylation to produce energy whereas cancer cells have developed an altered metabolism that allows them to sustain higher proliferation rates.
Cancer cells could predominantly produce energy by glycolysis even in the presence of oxygen.
This alternative metabolic characteristic is known as the “Warburg Effect.” Although the exact mechanisms underlying the Warburg effect are unclear, recent progress indicates that glycolytic pathway of cancer cells could be a critical target for drug discovery.
With a long history in cancer treatment, traditional Chinese medicine (TCM) is recognized as a valuable source for seeking bioactive anticancer compounds.
A great progress has been made to identify active compounds from herbal medicine targeting on glycolysis for cancer treatment.
Herein, we provide an overall picture of the current understanding of the molecular targets in the cancer glycolytic pathway and reviewed active compounds from Chinese herbal medicine with the potentials to inhibit the metabolic targets for cancer treatment.
Combination of TCM with conventional therapies will provide an attractive strategy for improving clinical outcome in cancer treatment.
American Psychological Association (APA)
Wang, Zhiyu& Wang, Neng& Chen, Jianping& Shen, Jiangang. 2012. Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-992734
Modern Language Association (MLA)
Wang, Zhiyu…[et al.]. Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-992734
American Medical Association (AMA)
Wang, Zhiyu& Wang, Neng& Chen, Jianping& Shen, Jiangang. Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-992734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992734