Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy

Joint Authors

Shen, Jiangang
Wang, Zhiyu
Wang, Neng
Chen, Jianping

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-07-12

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Medicine

Abstract EN

Molecular-targeted therapy has been developed for cancer chemoprevention and treatment.

Cancer cells have different metabolic properties from normal cells.

Normal cells mostly rely upon the process of mitochondrial oxidative phosphorylation to produce energy whereas cancer cells have developed an altered metabolism that allows them to sustain higher proliferation rates.

Cancer cells could predominantly produce energy by glycolysis even in the presence of oxygen.

This alternative metabolic characteristic is known as the “Warburg Effect.” Although the exact mechanisms underlying the Warburg effect are unclear, recent progress indicates that glycolytic pathway of cancer cells could be a critical target for drug discovery.

With a long history in cancer treatment, traditional Chinese medicine (TCM) is recognized as a valuable source for seeking bioactive anticancer compounds.

A great progress has been made to identify active compounds from herbal medicine targeting on glycolysis for cancer treatment.

Herein, we provide an overall picture of the current understanding of the molecular targets in the cancer glycolytic pathway and reviewed active compounds from Chinese herbal medicine with the potentials to inhibit the metabolic targets for cancer treatment.

Combination of TCM with conventional therapies will provide an attractive strategy for improving clinical outcome in cancer treatment.

American Psychological Association (APA)

Wang, Zhiyu& Wang, Neng& Chen, Jianping& Shen, Jiangang. 2012. Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-992734

Modern Language Association (MLA)

Wang, Zhiyu…[et al.]. Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-992734

American Medical Association (AMA)

Wang, Zhiyu& Wang, Neng& Chen, Jianping& Shen, Jiangang. Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-992734

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-992734