Evaluation of Chinese-Herbal-Medicine-Induced Herb-Drug Interactions: Focusing on Organic Anion Transporter 1
المؤلفون المشاركون
Lin, Chang-Ching
Fan, Hsien-Yuan
Kuo, Chien-Wen
Pao, Li-Heng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-04
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The consumption of Chinese herbal medicines (CHMs) is increasing exponentially.
Many patients utilize CHMs concomitantly with prescription drugs in great frequency.
Herb-drug interaction has hence become an important focus of study.
Transporter-mediated herb-drug interactions have the potential to seriously influence drug efficacy and toxicity.
Since organic anion transporter 1 (OAT1) is crucial in renal active secretion and drug-drug interactions, the possibility of modulation of OAT1-mediated drug transport should be seriously concerned.
Sixty-three clinically used CHMs were evaluated in the study.
An hOAT1-overexpressing cell line was used for the in vitro CHMs screening, and the effective candidates were administered to Wistar rats to access renal hemodynamics.
The regulation of OAT1 mRNA expression was also examined for further evidence of CHMs affecting OAT1-mediated transport.
Among all the 63 CHMs, formulae Gui Zhi Fu Ling Wan (GZ) and Chia Wei Hsiao Yao San (CW) exhibited significant inhibitions on hOAT1-mediated [3H]-PAH uptake in vitro and PAH clearance and net secretion in vivo.
Moreover, GZ showed concentration-dependent manners both in vitro and in vivo, and the decrease of rOAT1 mRNA expression indicated that GZ not only inhibited function of OAT1 but also suppressed expression of OAT1.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Chang-Ching& Fan, Hsien-Yuan& Kuo, Chien-Wen& Pao, Li-Heng. 2012. Evaluation of Chinese-Herbal-Medicine-Induced Herb-Drug Interactions: Focusing on Organic Anion Transporter 1. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992829
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Chang-Ching…[et al.]. Evaluation of Chinese-Herbal-Medicine-Induced Herb-Drug Interactions: Focusing on Organic Anion Transporter 1. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-992829
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Chang-Ching& Fan, Hsien-Yuan& Kuo, Chien-Wen& Pao, Li-Heng. Evaluation of Chinese-Herbal-Medicine-Induced Herb-Drug Interactions: Focusing on Organic Anion Transporter 1. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992829
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992829
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر