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Evaluation of Chinese-Herbal-Medicine-Induced Herb-Drug Interactions: Focusing on Organic Anion Transporter 1
Joint Authors
Lin, Chang-Ching
Fan, Hsien-Yuan
Kuo, Chien-Wen
Pao, Li-Heng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The consumption of Chinese herbal medicines (CHMs) is increasing exponentially.
Many patients utilize CHMs concomitantly with prescription drugs in great frequency.
Herb-drug interaction has hence become an important focus of study.
Transporter-mediated herb-drug interactions have the potential to seriously influence drug efficacy and toxicity.
Since organic anion transporter 1 (OAT1) is crucial in renal active secretion and drug-drug interactions, the possibility of modulation of OAT1-mediated drug transport should be seriously concerned.
Sixty-three clinically used CHMs were evaluated in the study.
An hOAT1-overexpressing cell line was used for the in vitro CHMs screening, and the effective candidates were administered to Wistar rats to access renal hemodynamics.
The regulation of OAT1 mRNA expression was also examined for further evidence of CHMs affecting OAT1-mediated transport.
Among all the 63 CHMs, formulae Gui Zhi Fu Ling Wan (GZ) and Chia Wei Hsiao Yao San (CW) exhibited significant inhibitions on hOAT1-mediated [3H]-PAH uptake in vitro and PAH clearance and net secretion in vivo.
Moreover, GZ showed concentration-dependent manners both in vitro and in vivo, and the decrease of rOAT1 mRNA expression indicated that GZ not only inhibited function of OAT1 but also suppressed expression of OAT1.
American Psychological Association (APA)
Lin, Chang-Ching& Fan, Hsien-Yuan& Kuo, Chien-Wen& Pao, Li-Heng. 2012. Evaluation of Chinese-Herbal-Medicine-Induced Herb-Drug Interactions: Focusing on Organic Anion Transporter 1. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992829
Modern Language Association (MLA)
Lin, Chang-Ching…[et al.]. Evaluation of Chinese-Herbal-Medicine-Induced Herb-Drug Interactions: Focusing on Organic Anion Transporter 1. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-992829
American Medical Association (AMA)
Lin, Chang-Ching& Fan, Hsien-Yuan& Kuo, Chien-Wen& Pao, Li-Heng. Evaluation of Chinese-Herbal-Medicine-Induced Herb-Drug Interactions: Focusing on Organic Anion Transporter 1. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992829