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Caffeic Acid Phenylethyl Amide Protects against the Metabolic Consequences in Diabetes Mellitus Induced by Diet and Streptozocin
المؤلفون المشاركون
Weng, Yi-Chun
Chuang, Sung-Ting
Lin, Yen-Chu
Chuang, Cheng-Fung
Chi, Tzong-Cherng
Chiu, Hsi-Lin
Kuo, Yueh-Hsiung
Su, Ming-Jai
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-24
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Caffeic acid phenyl ester is distributed wildly in nature and has antidiabetic and cardiovascular protective effects.
However, rapid decomposition by esterase leads to its low bioavailability in vivo.
In this study, chronic metabolic and cardiovascular effects of oral caffeic acid phenylethyl amide, whose structure is similar to caffeic acid phenyl ester and resveratrol, were investigated in ICR mice.
We found that caffeic acid phenylethyl amide protected against diet or streptozocin-induced metabolic changes increased coronary flow and decreased infarct size after global ischemia-reperfusion in Langendorff perfused heart.
Further study indicated that at least two pathways might be involved in such beneficial effects: the induction of the antioxidant protein MnSOD and the decrease of the proinflammatory cytokine TNFα and NFκB in the liver.
However, the detailed mechanisms of caffeic acid phenylethyl amide need further studies.
In summary, this study demonstrated the protective potential of chronic treatment of caffeic acid phenylethyl amide against the metabolic consequences in diabetes mellitus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Weng, Yi-Chun& Chuang, Sung-Ting& Lin, Yen-Chu& Chuang, Cheng-Fung& Chi, Tzong-Cherng& Chiu, Hsi-Lin…[et al.]. 2012. Caffeic Acid Phenylethyl Amide Protects against the Metabolic Consequences in Diabetes Mellitus Induced by Diet and Streptozocin. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992859
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Weng, Yi-Chun…[et al.]. Caffeic Acid Phenylethyl Amide Protects against the Metabolic Consequences in Diabetes Mellitus Induced by Diet and Streptozocin. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-992859
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Weng, Yi-Chun& Chuang, Sung-Ting& Lin, Yen-Chu& Chuang, Cheng-Fung& Chi, Tzong-Cherng& Chiu, Hsi-Lin…[et al.]. Caffeic Acid Phenylethyl Amide Protects against the Metabolic Consequences in Diabetes Mellitus Induced by Diet and Streptozocin. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992859
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992859
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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