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Caffeic Acid Phenylethyl Amide Protects against the Metabolic Consequences in Diabetes Mellitus Induced by Diet and Streptozocin
Joint Authors
Weng, Yi-Chun
Chuang, Sung-Ting
Lin, Yen-Chu
Chuang, Cheng-Fung
Chi, Tzong-Cherng
Chiu, Hsi-Lin
Kuo, Yueh-Hsiung
Su, Ming-Jai
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Caffeic acid phenyl ester is distributed wildly in nature and has antidiabetic and cardiovascular protective effects.
However, rapid decomposition by esterase leads to its low bioavailability in vivo.
In this study, chronic metabolic and cardiovascular effects of oral caffeic acid phenylethyl amide, whose structure is similar to caffeic acid phenyl ester and resveratrol, were investigated in ICR mice.
We found that caffeic acid phenylethyl amide protected against diet or streptozocin-induced metabolic changes increased coronary flow and decreased infarct size after global ischemia-reperfusion in Langendorff perfused heart.
Further study indicated that at least two pathways might be involved in such beneficial effects: the induction of the antioxidant protein MnSOD and the decrease of the proinflammatory cytokine TNFα and NFκB in the liver.
However, the detailed mechanisms of caffeic acid phenylethyl amide need further studies.
In summary, this study demonstrated the protective potential of chronic treatment of caffeic acid phenylethyl amide against the metabolic consequences in diabetes mellitus.
American Psychological Association (APA)
Weng, Yi-Chun& Chuang, Sung-Ting& Lin, Yen-Chu& Chuang, Cheng-Fung& Chi, Tzong-Cherng& Chiu, Hsi-Lin…[et al.]. 2012. Caffeic Acid Phenylethyl Amide Protects against the Metabolic Consequences in Diabetes Mellitus Induced by Diet and Streptozocin. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992859
Modern Language Association (MLA)
Weng, Yi-Chun…[et al.]. Caffeic Acid Phenylethyl Amide Protects against the Metabolic Consequences in Diabetes Mellitus Induced by Diet and Streptozocin. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-992859
American Medical Association (AMA)
Weng, Yi-Chun& Chuang, Sung-Ting& Lin, Yen-Chu& Chuang, Cheng-Fung& Chi, Tzong-Cherng& Chiu, Hsi-Lin…[et al.]. Caffeic Acid Phenylethyl Amide Protects against the Metabolic Consequences in Diabetes Mellitus Induced by Diet and Streptozocin. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992859