Investigating Endothelial Activation and Oxidative Stress in relation to Glycaemic Control in a Multiethnic Population
المؤلفون المشاركون
Talbot, D. S. C.
Brady, E. M.
Davies, Melanie J.
Morris, D. H.
Khunti, Kamlesh
Sattar, N.
Webb, D. R.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-06
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
An exploration of ethnic differences in measures of oxidative stress and endothelial activation in relation to known cardiovascular risk factors within South Asians (SA) and White Europeans (WE) residing in the UK.
Methods.
202 participants within a UK multiethnic population provided biomedical and anthropometric data.
Human urinary 2,3-dinor-8-iso-prostaglandin-F1α and plasma ICAM-1 were quantified as measures of oxidative stress and endothelial activation, respectively.
Results.
2,3-Dinor-8-iso-prostaglandin-F1α levels were significantly higher in the SA group compared to WE group (10.36 (95% CI: 9.09, 11.79) versus 8.46 (7.71, 9.29), P=0.021) after adjustment for age, gender, smoking status, body weight, HbA1c, and medication.
Oxidative stress was positively associated with HbA1c (β=1.08, 95% CI:1.02, 1.14, P=0.009), fasting (β=1.06, 95% CI: 1.02, 1.10, P=0.002), and 2 hr glucose (β=1.02, 95% CI: 1.00, 1.04, P=0.052).
In each adjusted model, SA continued to have elevated levels of oxidative stress compared to WE.
ICAM-1 levels were significantly higher in the composite IGR group compared to the normoglycaemic group (P<0.001).
No ethnic differences in ICAM-1 were observed.
Conclusion.
These results suggest that SA are more susceptible to the detrimental effects of hyperglycaemia-induced oxidative stress at lower blood glucose thresholds than WE.
Further research into the potential mechanisms involved is warranted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Brady, E. M.& Webb, D. R.& Morris, D. H.& Khunti, Kamlesh& Talbot, D. S. C.& Sattar, N.…[et al.]. 2012. Investigating Endothelial Activation and Oxidative Stress in relation to Glycaemic Control in a Multiethnic Population. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-993976
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Brady, E. M.…[et al.]. Investigating Endothelial Activation and Oxidative Stress in relation to Glycaemic Control in a Multiethnic Population. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-993976
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Brady, E. M.& Webb, D. R.& Morris, D. H.& Khunti, Kamlesh& Talbot, D. S. C.& Sattar, N.…[et al.]. Investigating Endothelial Activation and Oxidative Stress in relation to Glycaemic Control in a Multiethnic Population. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-993976
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-993976
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر