Investigating Endothelial Activation and Oxidative Stress in relation to Glycaemic Control in a Multiethnic Population
Joint Authors
Talbot, D. S. C.
Brady, E. M.
Davies, Melanie J.
Morris, D. H.
Khunti, Kamlesh
Sattar, N.
Webb, D. R.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
An exploration of ethnic differences in measures of oxidative stress and endothelial activation in relation to known cardiovascular risk factors within South Asians (SA) and White Europeans (WE) residing in the UK.
Methods.
202 participants within a UK multiethnic population provided biomedical and anthropometric data.
Human urinary 2,3-dinor-8-iso-prostaglandin-F1α and plasma ICAM-1 were quantified as measures of oxidative stress and endothelial activation, respectively.
Results.
2,3-Dinor-8-iso-prostaglandin-F1α levels were significantly higher in the SA group compared to WE group (10.36 (95% CI: 9.09, 11.79) versus 8.46 (7.71, 9.29), P=0.021) after adjustment for age, gender, smoking status, body weight, HbA1c, and medication.
Oxidative stress was positively associated with HbA1c (β=1.08, 95% CI:1.02, 1.14, P=0.009), fasting (β=1.06, 95% CI: 1.02, 1.10, P=0.002), and 2 hr glucose (β=1.02, 95% CI: 1.00, 1.04, P=0.052).
In each adjusted model, SA continued to have elevated levels of oxidative stress compared to WE.
ICAM-1 levels were significantly higher in the composite IGR group compared to the normoglycaemic group (P<0.001).
No ethnic differences in ICAM-1 were observed.
Conclusion.
These results suggest that SA are more susceptible to the detrimental effects of hyperglycaemia-induced oxidative stress at lower blood glucose thresholds than WE.
Further research into the potential mechanisms involved is warranted.
American Psychological Association (APA)
Brady, E. M.& Webb, D. R.& Morris, D. H.& Khunti, Kamlesh& Talbot, D. S. C.& Sattar, N.…[et al.]. 2012. Investigating Endothelial Activation and Oxidative Stress in relation to Glycaemic Control in a Multiethnic Population. Journal of Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-993976
Modern Language Association (MLA)
Brady, E. M.…[et al.]. Investigating Endothelial Activation and Oxidative Stress in relation to Glycaemic Control in a Multiethnic Population. Journal of Diabetes Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-993976
American Medical Association (AMA)
Brady, E. M.& Webb, D. R.& Morris, D. H.& Khunti, Kamlesh& Talbot, D. S. C.& Sattar, N.…[et al.]. Investigating Endothelial Activation and Oxidative Stress in relation to Glycaemic Control in a Multiethnic Population. Journal of Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-993976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-993976