CancerTestis Antigen MAGE-C1CT7: New Target for Multiple Myeloma Therapy

المؤلفون المشاركون

de Carvalho, Fabricio
Vettore, André L.
Colleoni, Gisele W. B.

المصدر

Journal of Immunology Research

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-03-11

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأحياء

الملخص EN

Cancer/Testis Antigens (CTAs) are a promising class of tumor antigens that have a limited expression in somatic tissues (testis, ovary, fetal, and placental cells).

Aberrant expression of CTAs in cancer cells may lead to abnormal chromosome segregation and aneuploidy.

CTAs are regulated by epigenetic mechanisms (DNA methylation and acetylation of histones) and are attractive targets for immunotherapy in cancer because the gonads are immune privileged organs and anti-CTA immune response can be tumor-specific.

Multiple myeloma (MM) is an incurable hematological malignancy, and several CTAs have been detected in many MM cell lines and patients.

Among CTAs expressed in MM we must highlight the MAGE-C1/CT7 located on the X chromosome and expressed specificity in the malignant plasma cells.

MAGE-C1/CT7 seems to be related to disease progression and functional studies suggests that this CTA might play a role in cell cycle and mainly in survival of malignant plasma cells, protecting myeloma cells against spontaneous as well as drug-induced apoptosis.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

de Carvalho, Fabricio& Vettore, André L.& Colleoni, Gisele W. B.. 2012. CancerTestis Antigen MAGE-C1CT7: New Target for Multiple Myeloma Therapy. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994382

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

de Carvalho, Fabricio…[et al.]. CancerTestis Antigen MAGE-C1CT7: New Target for Multiple Myeloma Therapy. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-994382

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

de Carvalho, Fabricio& Vettore, André L.& Colleoni, Gisele W. B.. CancerTestis Antigen MAGE-C1CT7: New Target for Multiple Myeloma Therapy. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994382

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-994382