CancerTestis Antigen MAGE-C1CT7: New Target for Multiple Myeloma Therapy
Joint Authors
de Carvalho, Fabricio
Vettore, André L.
Colleoni, Gisele W. B.
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cancer/Testis Antigens (CTAs) are a promising class of tumor antigens that have a limited expression in somatic tissues (testis, ovary, fetal, and placental cells).
Aberrant expression of CTAs in cancer cells may lead to abnormal chromosome segregation and aneuploidy.
CTAs are regulated by epigenetic mechanisms (DNA methylation and acetylation of histones) and are attractive targets for immunotherapy in cancer because the gonads are immune privileged organs and anti-CTA immune response can be tumor-specific.
Multiple myeloma (MM) is an incurable hematological malignancy, and several CTAs have been detected in many MM cell lines and patients.
Among CTAs expressed in MM we must highlight the MAGE-C1/CT7 located on the X chromosome and expressed specificity in the malignant plasma cells.
MAGE-C1/CT7 seems to be related to disease progression and functional studies suggests that this CTA might play a role in cell cycle and mainly in survival of malignant plasma cells, protecting myeloma cells against spontaneous as well as drug-induced apoptosis.
American Psychological Association (APA)
de Carvalho, Fabricio& Vettore, André L.& Colleoni, Gisele W. B.. 2012. CancerTestis Antigen MAGE-C1CT7: New Target for Multiple Myeloma Therapy. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994382
Modern Language Association (MLA)
de Carvalho, Fabricio…[et al.]. CancerTestis Antigen MAGE-C1CT7: New Target for Multiple Myeloma Therapy. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-994382
American Medical Association (AMA)
de Carvalho, Fabricio& Vettore, André L.& Colleoni, Gisele W. B.. CancerTestis Antigen MAGE-C1CT7: New Target for Multiple Myeloma Therapy. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994382
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994382