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Double Allogenic Mesenchymal Stem Cells Transplantations Could NotEnhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus
المؤلفون المشاركون
Chen, Wanjun
Akiyama, Kentaro
Li, Xia
Liu, Bujun
Wang, Dandan
Wang, Hong
Feng, Xuebing
Xu, Hu-Ji
Sun, Ling-Yun
Hua, Bingzhu
Yamaza, Takayoshi
Shi, Songtao
Zhang, Huayong
المصدر
Journal of Immunology Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The clinical trial of allogenic mesenchymal stem cells (MSCs) transplantation for refractory SLE patients has shown significant safety and efficacy profiles.
However, the optimum frequency of the MSCs transplantation (MSCT) is unknown.
This study was undertaken to observe whether double transplantations of MSCs is superior to single transplantation.
Fifty-eight refractory SLE patients were enrolled in this study, in which 30 were randomly given single MSCT, and the other 28 were given double MSCT.
Patients were followed up for rates of survival, disease remission, and relapse, as well as transplantation-related adverse events.
SLE disease activity index (SLEDAI) and serologic features were evaluated.
Our results showed that no remarkable differences between single and double allogenic MSCT were found in terms of disease remission and relapse, amelioration of disease activity, and serum indexes in an SLE clinical trial with more than one year followup.
This study demonstrated that single MSCs transplantation at the dose of one million MSCs per kilogram of body weight was sufficient to induce disease remission for refractory SLE patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Dandan& Akiyama, Kentaro& Zhang, Huayong& Yamaza, Takayoshi& Li, Xia& Feng, Xuebing…[et al.]. 2012. Double Allogenic Mesenchymal Stem Cells Transplantations Could NotEnhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994390
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Dandan…[et al.]. Double Allogenic Mesenchymal Stem Cells Transplantations Could NotEnhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-994390
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Dandan& Akiyama, Kentaro& Zhang, Huayong& Yamaza, Takayoshi& Li, Xia& Feng, Xuebing…[et al.]. Double Allogenic Mesenchymal Stem Cells Transplantations Could NotEnhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994390
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-994390
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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