Double Allogenic Mesenchymal Stem Cells Transplantations Could NotEnhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus
Joint Authors
Chen, Wanjun
Akiyama, Kentaro
Li, Xia
Liu, Bujun
Wang, Dandan
Wang, Hong
Feng, Xuebing
Xu, Hu-Ji
Sun, Ling-Yun
Hua, Bingzhu
Yamaza, Takayoshi
Shi, Songtao
Zhang, Huayong
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The clinical trial of allogenic mesenchymal stem cells (MSCs) transplantation for refractory SLE patients has shown significant safety and efficacy profiles.
However, the optimum frequency of the MSCs transplantation (MSCT) is unknown.
This study was undertaken to observe whether double transplantations of MSCs is superior to single transplantation.
Fifty-eight refractory SLE patients were enrolled in this study, in which 30 were randomly given single MSCT, and the other 28 were given double MSCT.
Patients were followed up for rates of survival, disease remission, and relapse, as well as transplantation-related adverse events.
SLE disease activity index (SLEDAI) and serologic features were evaluated.
Our results showed that no remarkable differences between single and double allogenic MSCT were found in terms of disease remission and relapse, amelioration of disease activity, and serum indexes in an SLE clinical trial with more than one year followup.
This study demonstrated that single MSCs transplantation at the dose of one million MSCs per kilogram of body weight was sufficient to induce disease remission for refractory SLE patients.
American Psychological Association (APA)
Wang, Dandan& Akiyama, Kentaro& Zhang, Huayong& Yamaza, Takayoshi& Li, Xia& Feng, Xuebing…[et al.]. 2012. Double Allogenic Mesenchymal Stem Cells Transplantations Could NotEnhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994390
Modern Language Association (MLA)
Wang, Dandan…[et al.]. Double Allogenic Mesenchymal Stem Cells Transplantations Could NotEnhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-994390
American Medical Association (AMA)
Wang, Dandan& Akiyama, Kentaro& Zhang, Huayong& Yamaza, Takayoshi& Li, Xia& Feng, Xuebing…[et al.]. Double Allogenic Mesenchymal Stem Cells Transplantations Could NotEnhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994390
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994390