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Maternal Plasma Phosphatidylcholine Fatty Acids and Atopy and Wheeze in the Offspring at Age of 6 Years
المؤلفون المشاركون
Robinson, Sian M.
Lucas, Jane S. A.
Cooper, Cyrus
Godfrey, Keith M.
Pike, Katharine C.
Inskip, Hazel M.
Roberts, Graham C.
Calder, Philip C.
المصدر
Journal of Immunology Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-25
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Variation in exposure to polyunsaturated fatty acids (PUFAs) might influence the development of atopy, asthma, and wheeze.
This study aimed to determine whether differences in PUFA concentrations in maternal plasma phosphatidylcholine are associated with the risk of childhood wheeze or atopy.
For 865 term-born children, we measured phosphatidylcholine fatty acid composition in maternal plasma collected at 34 weeks’ gestation.
Wheezing was classified using questionnaires at 6, 12, 24, and 36 months and 6 years.
At age of 6 years, the children underwent skin prick testing, fractional exhaled nitric oxide (FENO) measurement, and spirometry.
Maternal n-6 fatty acids and the ratio of n-3 to n-6 fatty acids were not associated with childhood wheeze.
However, higher maternal eicosapentaenoic acid, docosahexaenoic acid, and total n-3 fatty acids were associated with reduced risk of non-atopic persistent/late wheeze (RR 0.57, 0.67 and 0.69, resp.
P=0.01, 0.015, and 0.021, resp.).
Maternal arachidonic acid was positively associated with FENO (P=0.024).
A higher ratio of linoleic acid to its unsaturated metabolic products was associated with reduced risk of skin sensitisation (RR 0.82, P=0.013).
These associations provide some support for the hypothesis that variation in exposure to n-6 and n-3 fatty acids during pregnancy influences the risk of childhood wheeze and atopy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pike, Katharine C.& Calder, Philip C.& Inskip, Hazel M.& Robinson, Sian M.& Roberts, Graham C.& Cooper, Cyrus…[et al.]. 2012. Maternal Plasma Phosphatidylcholine Fatty Acids and Atopy and Wheeze in the Offspring at Age of 6 Years. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-994440
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pike, Katharine C.…[et al.]. Maternal Plasma Phosphatidylcholine Fatty Acids and Atopy and Wheeze in the Offspring at Age of 6 Years. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-994440
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pike, Katharine C.& Calder, Philip C.& Inskip, Hazel M.& Robinson, Sian M.& Roberts, Graham C.& Cooper, Cyrus…[et al.]. Maternal Plasma Phosphatidylcholine Fatty Acids and Atopy and Wheeze in the Offspring at Age of 6 Years. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-994440
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-994440
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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