Maternal Plasma Phosphatidylcholine Fatty Acids and Atopy and Wheeze in the Offspring at Age of 6 Years
Joint Authors
Robinson, Sian M.
Lucas, Jane S. A.
Cooper, Cyrus
Godfrey, Keith M.
Pike, Katharine C.
Inskip, Hazel M.
Roberts, Graham C.
Calder, Philip C.
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Variation in exposure to polyunsaturated fatty acids (PUFAs) might influence the development of atopy, asthma, and wheeze.
This study aimed to determine whether differences in PUFA concentrations in maternal plasma phosphatidylcholine are associated with the risk of childhood wheeze or atopy.
For 865 term-born children, we measured phosphatidylcholine fatty acid composition in maternal plasma collected at 34 weeks’ gestation.
Wheezing was classified using questionnaires at 6, 12, 24, and 36 months and 6 years.
At age of 6 years, the children underwent skin prick testing, fractional exhaled nitric oxide (FENO) measurement, and spirometry.
Maternal n-6 fatty acids and the ratio of n-3 to n-6 fatty acids were not associated with childhood wheeze.
However, higher maternal eicosapentaenoic acid, docosahexaenoic acid, and total n-3 fatty acids were associated with reduced risk of non-atopic persistent/late wheeze (RR 0.57, 0.67 and 0.69, resp.
P=0.01, 0.015, and 0.021, resp.).
Maternal arachidonic acid was positively associated with FENO (P=0.024).
A higher ratio of linoleic acid to its unsaturated metabolic products was associated with reduced risk of skin sensitisation (RR 0.82, P=0.013).
These associations provide some support for the hypothesis that variation in exposure to n-6 and n-3 fatty acids during pregnancy influences the risk of childhood wheeze and atopy.
American Psychological Association (APA)
Pike, Katharine C.& Calder, Philip C.& Inskip, Hazel M.& Robinson, Sian M.& Roberts, Graham C.& Cooper, Cyrus…[et al.]. 2012. Maternal Plasma Phosphatidylcholine Fatty Acids and Atopy and Wheeze in the Offspring at Age of 6 Years. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-994440
Modern Language Association (MLA)
Pike, Katharine C.…[et al.]. Maternal Plasma Phosphatidylcholine Fatty Acids and Atopy and Wheeze in the Offspring at Age of 6 Years. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-994440
American Medical Association (AMA)
Pike, Katharine C.& Calder, Philip C.& Inskip, Hazel M.& Robinson, Sian M.& Roberts, Graham C.& Cooper, Cyrus…[et al.]. Maternal Plasma Phosphatidylcholine Fatty Acids and Atopy and Wheeze in the Offspring at Age of 6 Years. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-994440
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994440