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Is the BCG Vaccine Safe for Undernourished Individuals?
المؤلفون المشاركون
Chiuso-Minicucci, Fernanda
Ishikawa, Larissa Lumi Watanabe
Zorzella-Pezavento, Sofia Fernanda Gonçalves
França, Thais Graziela Donegá
Sartori, Alexandrina
Peres, Raphael Sanches
da Rosa, Larissa Camargo
المصدر
Journal of Immunology Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-10
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Cellular immunity is critical for protection against tuberculosis, but its integrity is compromised during undernutrition.
The present study was designed to evaluate if the attenuated mycobacterium BCG is a safe vaccine for undernourished individuals.
An experimental model of undernutrition was established by subjecting BALB/c mice to dietary restriction.
These animals received 70% of the amount of food consumed by the healthy control group and exhibited physiological alterations compatible with malnutrition, including body weight loss, reduced levels of triglycerides and glucose, and reduced lymphocyte numbers.
Undernourished mice were immunized with BCG, and the mycobacterial loads in lymph nodes, spleen, liver, lungs, and thymus were determined.
A much higher proportion of undernourished mice exhibited bacterial dissemination to the lymph nodes, spleen and liver.
In addition, only undernourished animals had bacteria in the lungs and thymus.
Concomitant with higher mycobacterial loads and more widespread BCG dissemination in undernourished mice, production of TNF-α, IFN-γ, and IL-10 was also diminished in these mice.
Taken together, these results indicate that BCG infection is more severe in undernourished mice.
Whether a similar phenomenon exists in undernourished children or not remains to be thoroughly investigated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ishikawa, Larissa Lumi Watanabe& França, Thais Graziela Donegá& Peres, Raphael Sanches& Chiuso-Minicucci, Fernanda& Zorzella-Pezavento, Sofia Fernanda Gonçalves& Sartori, Alexandrina…[et al.]. 2012. Is the BCG Vaccine Safe for Undernourished Individuals?. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-996784
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
França, Thais Graziela Donegá…[et al.]. Is the BCG Vaccine Safe for Undernourished Individuals?. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-996784
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ishikawa, Larissa Lumi Watanabe& França, Thais Graziela Donegá& Peres, Raphael Sanches& Chiuso-Minicucci, Fernanda& Zorzella-Pezavento, Sofia Fernanda Gonçalves& Sartori, Alexandrina…[et al.]. Is the BCG Vaccine Safe for Undernourished Individuals?. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-996784
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-996784
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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