Is the BCG Vaccine Safe for Undernourished Individuals?
Joint Authors
Chiuso-Minicucci, Fernanda
Ishikawa, Larissa Lumi Watanabe
Zorzella-Pezavento, Sofia Fernanda Gonçalves
França, Thais Graziela Donegá
Sartori, Alexandrina
Peres, Raphael Sanches
da Rosa, Larissa Camargo
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cellular immunity is critical for protection against tuberculosis, but its integrity is compromised during undernutrition.
The present study was designed to evaluate if the attenuated mycobacterium BCG is a safe vaccine for undernourished individuals.
An experimental model of undernutrition was established by subjecting BALB/c mice to dietary restriction.
These animals received 70% of the amount of food consumed by the healthy control group and exhibited physiological alterations compatible with malnutrition, including body weight loss, reduced levels of triglycerides and glucose, and reduced lymphocyte numbers.
Undernourished mice were immunized with BCG, and the mycobacterial loads in lymph nodes, spleen, liver, lungs, and thymus were determined.
A much higher proportion of undernourished mice exhibited bacterial dissemination to the lymph nodes, spleen and liver.
In addition, only undernourished animals had bacteria in the lungs and thymus.
Concomitant with higher mycobacterial loads and more widespread BCG dissemination in undernourished mice, production of TNF-α, IFN-γ, and IL-10 was also diminished in these mice.
Taken together, these results indicate that BCG infection is more severe in undernourished mice.
Whether a similar phenomenon exists in undernourished children or not remains to be thoroughly investigated.
American Psychological Association (APA)
Ishikawa, Larissa Lumi Watanabe& França, Thais Graziela Donegá& Peres, Raphael Sanches& Chiuso-Minicucci, Fernanda& Zorzella-Pezavento, Sofia Fernanda Gonçalves& Sartori, Alexandrina…[et al.]. 2012. Is the BCG Vaccine Safe for Undernourished Individuals?. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-996784
Modern Language Association (MLA)
França, Thais Graziela Donegá…[et al.]. Is the BCG Vaccine Safe for Undernourished Individuals?. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-996784
American Medical Association (AMA)
Ishikawa, Larissa Lumi Watanabe& França, Thais Graziela Donegá& Peres, Raphael Sanches& Chiuso-Minicucci, Fernanda& Zorzella-Pezavento, Sofia Fernanda Gonçalves& Sartori, Alexandrina…[et al.]. Is the BCG Vaccine Safe for Undernourished Individuals?. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-996784
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996784