In Vitro Degradation of PHBV Scaffolds and nHAPHBV Composite Scaffolds Containing Hydroxyapatite Nanoparticles for Bone Tissue Engineering
المؤلفون المشاركون
Sultana, Naznin
Khan, Tareef Hayat
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-17
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
This paper investigated the long-term in vitro degradation properties of scaffolds based on biodegradable polymers and osteoconductive bioceramic/polymer composite materials for the application of bone tissue engineering.
The three-dimensional porous scaffolds were fabricated using emulsion-freezing/freeze-drying technique using poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) which is a natural biodegradable and biocompatible polymer.
Nanosized hydroxyapatite (nHA) particles were successfully incorporated into the PHBV scaffolds to render the scaffolds osteoconductive.
The PHBV and nHA/PHBV scaffolds were systematically evaluated using various techniques in terms of mechanical strength, porosity, porous morphology, and in vitro degradation.
PHBV and nHA/PHBV scaffolds degraded over time in phosphate-buffered saline at 37°C.
PHBV polymer scaffolds exhibited slow molecular weight loss and weight loss in the in vitro physiological environment.
Accelerated weight loss was observed in nHA incorporated PHBV composite scaffolds.
An increasing trend of crystallinity was observed during the initial period of degradation time.
The compressive properties decreased more than 40% after 5-month in vitro degradation.
Together with interconnected pores, high porosity, suitable mechanical properties, and slow degradation profile obtained from long-term degradation studies, the PHBV scaffolds and osteoconductive nHA/PHBV composite scaffolds showed promises for bone tissue engineering application.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sultana, Naznin& Khan, Tareef Hayat. 2012. In Vitro Degradation of PHBV Scaffolds and nHAPHBV Composite Scaffolds Containing Hydroxyapatite Nanoparticles for Bone Tissue Engineering. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-997301
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sultana, Naznin& Khan, Tareef Hayat. In Vitro Degradation of PHBV Scaffolds and nHAPHBV Composite Scaffolds Containing Hydroxyapatite Nanoparticles for Bone Tissue Engineering. Journal of Nanomaterials No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-997301
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sultana, Naznin& Khan, Tareef Hayat. In Vitro Degradation of PHBV Scaffolds and nHAPHBV Composite Scaffolds Containing Hydroxyapatite Nanoparticles for Bone Tissue Engineering. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-997301
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-997301
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر