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In Vitro Degradation of PHBV Scaffolds and nHAPHBV Composite Scaffolds Containing Hydroxyapatite Nanoparticles for Bone Tissue Engineering
Joint Authors
Sultana, Naznin
Khan, Tareef Hayat
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This paper investigated the long-term in vitro degradation properties of scaffolds based on biodegradable polymers and osteoconductive bioceramic/polymer composite materials for the application of bone tissue engineering.
The three-dimensional porous scaffolds were fabricated using emulsion-freezing/freeze-drying technique using poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) which is a natural biodegradable and biocompatible polymer.
Nanosized hydroxyapatite (nHA) particles were successfully incorporated into the PHBV scaffolds to render the scaffolds osteoconductive.
The PHBV and nHA/PHBV scaffolds were systematically evaluated using various techniques in terms of mechanical strength, porosity, porous morphology, and in vitro degradation.
PHBV and nHA/PHBV scaffolds degraded over time in phosphate-buffered saline at 37°C.
PHBV polymer scaffolds exhibited slow molecular weight loss and weight loss in the in vitro physiological environment.
Accelerated weight loss was observed in nHA incorporated PHBV composite scaffolds.
An increasing trend of crystallinity was observed during the initial period of degradation time.
The compressive properties decreased more than 40% after 5-month in vitro degradation.
Together with interconnected pores, high porosity, suitable mechanical properties, and slow degradation profile obtained from long-term degradation studies, the PHBV scaffolds and osteoconductive nHA/PHBV composite scaffolds showed promises for bone tissue engineering application.
American Psychological Association (APA)
Sultana, Naznin& Khan, Tareef Hayat. 2012. In Vitro Degradation of PHBV Scaffolds and nHAPHBV Composite Scaffolds Containing Hydroxyapatite Nanoparticles for Bone Tissue Engineering. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-997301
Modern Language Association (MLA)
Sultana, Naznin& Khan, Tareef Hayat. In Vitro Degradation of PHBV Scaffolds and nHAPHBV Composite Scaffolds Containing Hydroxyapatite Nanoparticles for Bone Tissue Engineering. Journal of Nanomaterials No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-997301
American Medical Association (AMA)
Sultana, Naznin& Khan, Tareef Hayat. In Vitro Degradation of PHBV Scaffolds and nHAPHBV Composite Scaffolds Containing Hydroxyapatite Nanoparticles for Bone Tissue Engineering. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-997301
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-997301