Screening the Most Effective Variables on Physical Properties of Folate-Targeted DextranRetinoic Acid Micelles by Taguchi Design
المؤلفون المشاركون
Varshosaz, Jaleh
Nayebsadrian, M.
Rostami, M.
Hassanzadeh, Farshid
Banitalebi, M.
Sadeghi-Aliabadi, Hojjat
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Amphiphilic copolymers with self-assembling properties produce micelles in aqueous solutions and are made of two hydrophilic and hydrophobic segments.
The objective of this study was optimization of the production of folate-conjugated dextran/retinoic acid (DEX/RA) micelles of doxorubicin.
Micelles were prepared by direct dissolution method, and different effective parameters on their production were studied by a Taguchi design.
The studied variables included CMC of the copolymer, polymer and drug contents, DEX Mw, stirring time, and rate and temperature.
The effects of variables on responses of particle size, polydispersity index, zeta potential, drug loading, and release efficiency were studied.
The most effective factors on particle size were DEX Mw, CMC of the copolymer, and stirring rate.
Zeta potential and drug loading were more affected by the polymer content, DEX Mw, stirring time, and drug concentration.
Stirring time and rate and also temperature of water were more effective variables on drug release rate.
The optimum processing situation for micelles formation was obtained by copolymers with CMC <17 μg/mL and prepared from 20.1 mg copolymers of DEX Mw of 10000 and drug concentration of 15.9%.
The optimized temperature for micelles formation was 40.7°C, and stirring time was 1 hr at a rate of 560 rpm.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nayebsadrian, M.& Varshosaz, Jaleh& Hassanzadeh, Farshid& Sadeghi-Aliabadi, Hojjat& Banitalebi, M.& Rostami, M.. 2012. Screening the Most Effective Variables on Physical Properties of Folate-Targeted DextranRetinoic Acid Micelles by Taguchi Design. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-998571
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nayebsadrian, M.…[et al.]. Screening the Most Effective Variables on Physical Properties of Folate-Targeted DextranRetinoic Acid Micelles by Taguchi Design. Journal of Nanomaterials No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-998571
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nayebsadrian, M.& Varshosaz, Jaleh& Hassanzadeh, Farshid& Sadeghi-Aliabadi, Hojjat& Banitalebi, M.& Rostami, M.. Screening the Most Effective Variables on Physical Properties of Folate-Targeted DextranRetinoic Acid Micelles by Taguchi Design. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-998571
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-998571
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر