Screening the Most Effective Variables on Physical Properties of Folate-Targeted DextranRetinoic Acid Micelles by Taguchi Design
Joint Authors
Varshosaz, Jaleh
Nayebsadrian, M.
Rostami, M.
Hassanzadeh, Farshid
Banitalebi, M.
Sadeghi-Aliabadi, Hojjat
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Amphiphilic copolymers with self-assembling properties produce micelles in aqueous solutions and are made of two hydrophilic and hydrophobic segments.
The objective of this study was optimization of the production of folate-conjugated dextran/retinoic acid (DEX/RA) micelles of doxorubicin.
Micelles were prepared by direct dissolution method, and different effective parameters on their production were studied by a Taguchi design.
The studied variables included CMC of the copolymer, polymer and drug contents, DEX Mw, stirring time, and rate and temperature.
The effects of variables on responses of particle size, polydispersity index, zeta potential, drug loading, and release efficiency were studied.
The most effective factors on particle size were DEX Mw, CMC of the copolymer, and stirring rate.
Zeta potential and drug loading were more affected by the polymer content, DEX Mw, stirring time, and drug concentration.
Stirring time and rate and also temperature of water were more effective variables on drug release rate.
The optimum processing situation for micelles formation was obtained by copolymers with CMC <17 μg/mL and prepared from 20.1 mg copolymers of DEX Mw of 10000 and drug concentration of 15.9%.
The optimized temperature for micelles formation was 40.7°C, and stirring time was 1 hr at a rate of 560 rpm.
American Psychological Association (APA)
Nayebsadrian, M.& Varshosaz, Jaleh& Hassanzadeh, Farshid& Sadeghi-Aliabadi, Hojjat& Banitalebi, M.& Rostami, M.. 2012. Screening the Most Effective Variables on Physical Properties of Folate-Targeted DextranRetinoic Acid Micelles by Taguchi Design. Journal of Nanomaterials،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-998571
Modern Language Association (MLA)
Nayebsadrian, M.…[et al.]. Screening the Most Effective Variables on Physical Properties of Folate-Targeted DextranRetinoic Acid Micelles by Taguchi Design. Journal of Nanomaterials No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-998571
American Medical Association (AMA)
Nayebsadrian, M.& Varshosaz, Jaleh& Hassanzadeh, Farshid& Sadeghi-Aliabadi, Hojjat& Banitalebi, M.& Rostami, M.. Screening the Most Effective Variables on Physical Properties of Folate-Targeted DextranRetinoic Acid Micelles by Taguchi Design. Journal of Nanomaterials. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-998571
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998571