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Association of the Resistin Gene Promoter Region Polymorphism with Kawasaki Disease in Chinese Children
المؤلفون المشاركون
Liu, Ruixi
He, Bo
Gao, Fang
Liu, Qian
Yi, Qijian
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
|Objectives.
The −420 C>G polymorphism located in the resistin gene (RETN) promoter has recently been suggested to play a potential role in proinflammatory conditions and cardiovascular disease.
This study investigated the association of the RETN promoter polymorphism with Kawasaki disease (KD) and its clinical parameters in Chinese children.
Methods.
We compared patients with complete KD to incomplete KD children.
Genotyping of the RETN promoter polymorphism was performed using MassARRAY system, and serum resistin levels were estimated using the sandwich enzyme immunoassay method.
Results.
There was no significant difference in RETN (−420 C>G) genotypes between KD and control groups.
However, the frequency of the G allele was higher in iKD patients than in cKD children due to a significantly increased frequency of the GG genotypes.
Serum levels of resistin were significantly higher in KD patients than in controls regardless of the presence of coronary artery lesions (CALs).
Conclusion.
The present findings suggest that while resistin may play a role in the pathogenesis of KD, there is no apparent association between CAL and the RETN (−420 C>G) gene polymorphism in KD children.
However, the diagnosis of iKD is challenging but can be supported by the presence of the G allele and the GG genotypes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Ruixi& He, Bo& Gao, Fang& Liu, Qian& Yi, Qijian. 2012. Association of the Resistin Gene Promoter Region Polymorphism with Kawasaki Disease in Chinese Children. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-998880
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Ruixi…[et al.]. Association of the Resistin Gene Promoter Region Polymorphism with Kawasaki Disease in Chinese Children. Mediators of Inflammation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-998880
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Ruixi& He, Bo& Gao, Fang& Liu, Qian& Yi, Qijian. Association of the Resistin Gene Promoter Region Polymorphism with Kawasaki Disease in Chinese Children. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-998880
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-998880
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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