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Association of the Resistin Gene Promoter Region Polymorphism with Kawasaki Disease in Chinese Children
Joint Authors
Liu, Ruixi
He, Bo
Gao, Fang
Liu, Qian
Yi, Qijian
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
|Objectives.
The −420 C>G polymorphism located in the resistin gene (RETN) promoter has recently been suggested to play a potential role in proinflammatory conditions and cardiovascular disease.
This study investigated the association of the RETN promoter polymorphism with Kawasaki disease (KD) and its clinical parameters in Chinese children.
Methods.
We compared patients with complete KD to incomplete KD children.
Genotyping of the RETN promoter polymorphism was performed using MassARRAY system, and serum resistin levels were estimated using the sandwich enzyme immunoassay method.
Results.
There was no significant difference in RETN (−420 C>G) genotypes between KD and control groups.
However, the frequency of the G allele was higher in iKD patients than in cKD children due to a significantly increased frequency of the GG genotypes.
Serum levels of resistin were significantly higher in KD patients than in controls regardless of the presence of coronary artery lesions (CALs).
Conclusion.
The present findings suggest that while resistin may play a role in the pathogenesis of KD, there is no apparent association between CAL and the RETN (−420 C>G) gene polymorphism in KD children.
However, the diagnosis of iKD is challenging but can be supported by the presence of the G allele and the GG genotypes.
American Psychological Association (APA)
Liu, Ruixi& He, Bo& Gao, Fang& Liu, Qian& Yi, Qijian. 2012. Association of the Resistin Gene Promoter Region Polymorphism with Kawasaki Disease in Chinese Children. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-998880
Modern Language Association (MLA)
Liu, Ruixi…[et al.]. Association of the Resistin Gene Promoter Region Polymorphism with Kawasaki Disease in Chinese Children. Mediators of Inflammation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-998880
American Medical Association (AMA)
Liu, Ruixi& He, Bo& Gao, Fang& Liu, Qian& Yi, Qijian. Association of the Resistin Gene Promoter Region Polymorphism with Kawasaki Disease in Chinese Children. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-998880
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-998880