Single nucleotide polymorphisms at erythropoietin, superoxide dismutase 1, splicing factor, arginineserin-rich 15 and plasmacytoma variant translocation genes association with diabetic nephropathy

Abstract EN

A number of genes have been identified in diabetic nephropathy.

Association between diabetes-associated nephropathy and polymorphisms in the erythropoietin (EPO) gene, variants in the superoxide dismutase 1 (SOD1) gene and plasmacytoma variant translocation 1 (PVT1) gene have been identified.

The EPO, SOD1:SFRS15 and PVT1 genes were genotyped using the single nucleotide polymorphism (SNP) technique in 38 diabetic nephropathy patients (Group 1) compared with 64 diabetic type 2 subjects without nephropathy (Group 2) at the Mubarak Alkabeer Hospital, Kuwait.

The frequency of the risk allele T of the EPO (rs1617640) gene was high in both groups (0.96 in Group 1 and 0.92 in Group 2).

Similarly, SNPs of the PVT1 (rs2720709) gene showed a higher frequency of the risk allele G in both groups (0.70 in the Group 1 and 0.68 in Group 2).

Although the frequency of the risk allele A was higher than the frequency of the non-risk allele C of the SOD1 : SFRS15 gene in both groups, the lowest probability value was observed in those gene SNPs (P = 0.05).

We observed that the A allele of the SOD1 : SFRS15 gene (rs17880135) was more frequently present in Group 1 (0.75) compared with Group 2 (0.62).

Susceptibility to diabetes-associated nephropathy is partially mediated by genetic predisposition, and screening tests may open the gate for new therapeutic approaches.