Prospect of Induced Pluripotent Stem Cell Genetic Repair to Cure Genetic Diseases
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
7
Abstract EN
In genetic diseases, where the cells are already damaged, the damaged cells can be replaced by new normal cells, which can be differentiated from iPSC.
To avoid immune rejection, iPSC from the patient’s own cell can be developed.
However, iPSC from the patients’s cell harbors the same genetic aberration.
Therefore, before differentiating the iPSCs into required cells, genetic repair should be done.
This review discusses the various technologies to repair the genetic aberration in patient-derived iPSC, or to prevent the genetic aberration to cause further damage in the iPSC-derived cells, such as Zn finger and TALE nuclease genetic editing, RNA interference technology, exon skipping, and gene transfer method.
In addition, the challenges in using the iPSC and the strategies to manage the hurdles are addressed.
American Psychological Association (APA)
Pawitan, Jeanne Adiwinata. 2012. Prospect of Induced Pluripotent Stem Cell Genetic Repair to Cure Genetic Diseases. Stem Cells International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1003030
Modern Language Association (MLA)
Pawitan, Jeanne Adiwinata. Prospect of Induced Pluripotent Stem Cell Genetic Repair to Cure Genetic Diseases. Stem Cells International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1003030
American Medical Association (AMA)
Pawitan, Jeanne Adiwinata. Prospect of Induced Pluripotent Stem Cell Genetic Repair to Cure Genetic Diseases. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1003030
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003030