Bilateral Transplantation of Allogenic Adult Human Bone Marrow-Derived Mesenchymal Stem Cells into the Subventricular Zone of Parkinson’s Disease: A Pilot Clinical Study
Joint Authors
Venkataramana, N. K.
Pal, Rakhi
Rao, Shailesh A. V.
Naik, Arun L.
Jan, Majahar
Nair, Rahul
Sanjeev, C. C.
Kamble, Ravindra B.
Murthy, D. P.
Chaitanya, Krishna
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-13
Country of Publication
Egypt
No. of Pages
12
Abstract EN
The progress of PD and its related disorders cannot be prevented with the medications available.
In this study, we recruited 8 PD and 4 PD plus patients between 5 to 15 years after diagnosis.
All patients received BM-MSCs bilaterally into the SVZ and were followed up for 12 months.
PD patients after therapy reported a mean improvement of 17.92% during “on” and 31.21% during “off” period on the UPDRS scoring system.
None of the patients increased their medication during the follow-up period.
Subjectively, the patients reported clarity in speech, reduction in tremors, rigidity, and freezing attacks.
The results correlated with the duration of the disease.
Those patients transplanted in the early stages of the disease (less than 5 years) showed more improvement and no further disease progression than the later stages (11–15 years).
However, the PD plus patients did not show any change in their clinical status after stem cell transplantation.
This study demonstrates the safety of adult allogenic human BM-MSCs transplanted into the SVZ of the brain and its efficacy in early-stage PD patients.
American Psychological Association (APA)
Venkataramana, N. K.& Pal, Rakhi& Rao, Shailesh A. V.& Naik, Arun L.& Jan, Majahar& Nair, Rahul…[et al.]. 2012. Bilateral Transplantation of Allogenic Adult Human Bone Marrow-Derived Mesenchymal Stem Cells into the Subventricular Zone of Parkinson’s Disease: A Pilot Clinical Study. Stem Cells International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1003131
Modern Language Association (MLA)
Venkataramana, N. K.…[et al.]. Bilateral Transplantation of Allogenic Adult Human Bone Marrow-Derived Mesenchymal Stem Cells into the Subventricular Zone of Parkinson’s Disease: A Pilot Clinical Study. Stem Cells International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1003131
American Medical Association (AMA)
Venkataramana, N. K.& Pal, Rakhi& Rao, Shailesh A. V.& Naik, Arun L.& Jan, Majahar& Nair, Rahul…[et al.]. Bilateral Transplantation of Allogenic Adult Human Bone Marrow-Derived Mesenchymal Stem Cells into the Subventricular Zone of Parkinson’s Disease: A Pilot Clinical Study. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1003131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003131