Age-Related Differences in the Effect of Psychological Distress on Mortality: Type D Personality in Younger versus Older Patients with Cardiac Arrhythmias

Abstract EN

Mixed findings in biobehavioral research on heart disease may partly be attributed to age-related differences in the prognostic value of psychological distress.

This study sought to test the hypothesis that Type D (distressed) personality contributes to an increased mortality risk following implantable cardioverter defibrillator (ICD) treatment in younger patients but not in older patients.

Methods.

The Type D Scale (DS14) was used to assess general psychological distress in 455 younger (≤70 y, m=59.1) and 134 older (>70 y, m=74.3) ICD patients.

End points were all-cause mortality and cardiac death after a median follow-up of 3.2 years.

Results.

Older patients had more advanced heart failure and a higher mortality rate (n=34/25%) than younger patients (n=60/13%), P=0.001.

Cardiac resynchronization therapy (CRT), but not Type D personality, was associated with increased mortality in older patients.

Among younger patients, however, Type D personality was associated with an adjusted hazard ratio = 1.91 (95% CI 1.09–3.34) and 2.26 (95% CI 1.16–4.41) for all-cause and cardiac mortality; other predictors were increasing age, CRT, appropriate shocks, ACE-inhibitors, and smoking.

Conclusion.

Type D personality was independently associated with all-cause and cardiac mortality in younger ICD patients but not in older patients.

Cardiovascular research needs to further explore age-related differences in psychosocial risk.