Protective Effect of Fermented Soybean Dried Extracts against TPA-Induced Oxidative Stress in Hairless Mice Skin
Joint Authors
Georgetti, Sandra R.
Casagrande, Rúbia
Vicentini, Fabiana T. M. C.
Baracat, Marcela M.
Verri, Waldiceu A.
Vieira, Maria José Fonseca
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study evaluated the chemical properties (polyphenol and genistein contents) of soybean extracts obtained by biotransformation and dried by spray dryer at different conditions and their in vivo ability to inhibit 12-O-tetradecanoylphorbol-13-acetate- (TPA-) induced biochemical alterations in the skin of hairless mice.
By comparing the obtained data with that of the well-known active soybean extract Isoflavin beta, we evaluated the influence of the fermentation and drying process in the extracts efficacy.
The results demonstrated that inlet gas temperature and adjuvant concentration for the extract drying process have significantly affected the total polyphenol contents and, to a minor degree, the genistein contents.
However, the effect of topical stimulus with TPA, an oxidative stress inducer, which caused significant depletion of reduced glutathione (GSH) and catalase, with increased levels of H2O2 and lipid peroxidation (MDA) in the skin of hairless mice, was significantly prevented by the soybean extracts treatment.
These results indicate that the spray drying processing resulted in a product capable of limiting the oxidative stress with possible therapeutic applicability as an antioxidant in pharmaceutical forms.
American Psychological Association (APA)
Georgetti, Sandra R.& Casagrande, Rúbia& Vicentini, Fabiana T. M. C.& Baracat, Marcela M.& Verri, Waldiceu A.& Vieira, Maria José Fonseca. 2013. Protective Effect of Fermented Soybean Dried Extracts against TPA-Induced Oxidative Stress in Hairless Mice Skin. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004049
Modern Language Association (MLA)
Georgetti, Sandra R.…[et al.]. Protective Effect of Fermented Soybean Dried Extracts against TPA-Induced Oxidative Stress in Hairless Mice Skin. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1004049
American Medical Association (AMA)
Georgetti, Sandra R.& Casagrande, Rúbia& Vicentini, Fabiana T. M. C.& Baracat, Marcela M.& Verri, Waldiceu A.& Vieira, Maria José Fonseca. Protective Effect of Fermented Soybean Dried Extracts against TPA-Induced Oxidative Stress in Hairless Mice Skin. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1004049
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004049