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The Importance of the Nurse Cells and Regulatory Cells in the Control of T Lymphocyte Responses
Joint Authors
Reyes García, María Guadalupe
García Tamayo, Fernando
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-26
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
T lymphocytes from the immune system are bone marrow-derived cells whose development and activities are carefully supervised by two sets of accessory cells.
In the thymus, the immature young T lymphocytes are engulfed by epithelial “nurse cells” and retained in vacuoles, where most of them (95%) are negatively selected and removed when they have an incomplete development or express high affinity autoreactive receptors.
The mature T lymphocytes that survive to this selection process leave the thymus and are controlled in the periphery by another subpopulation of accessory cells called “regulatory cells,” which reduce any excessive immune response and the risk of collateral injuries to healthy tissues.
By different times and procedures, nurse cells and regulatory cells control both the development and the functions of T lymphocyte subpopulations.
Disorders in the T lymphocytes development and migration have been observed in some parasitic diseases, which disrupt the thymic microenvironment of nurse cells.
In other cases, parasites stimulate rather than depress the functions of regulatory T cells decreasing T-mediated host damages.
This paper is a short review regarding some features of these accessory cells and their main interactions with T immature and mature lymphocytes.
The modulatory role that neurotransmitters and hormones play in these interactions is also revised.
American Psychological Association (APA)
Reyes García, María Guadalupe& García Tamayo, Fernando. 2012. The Importance of the Nurse Cells and Regulatory Cells in the Control of T Lymphocyte Responses. BioMed Research International،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1004091
Modern Language Association (MLA)
Reyes García, María Guadalupe& García Tamayo, Fernando. The Importance of the Nurse Cells and Regulatory Cells in the Control of T Lymphocyte Responses. BioMed Research International No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-1004091
American Medical Association (AMA)
Reyes García, María Guadalupe& García Tamayo, Fernando. The Importance of the Nurse Cells and Regulatory Cells in the Control of T Lymphocyte Responses. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1004091
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004091