The Study on Biocompatibility of Porous nHAPLGA Composite Scaffolds for Tissue Engineering with Rabbit Chondrocytes In Vitro
Joint Authors
Zeng, Yanjun
Chen, Lei
Zhu, Wei-Min
Fei, Zhi-Qiang
Chen, Jie-Lin
Xiong, Jian-Yi
Zhang, Ju-Feng
Duan, Li
Huang, Jianghong
Liu, Zhiyong
Wang, Daping
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
To examine the biocompatibility of a novel nanohydroxyapatite/poly[lactic-co-glycolic acid] (nHA/PLGA) composite and evaluate its feasibility as a scaffold for cartilage tissue engineering.
Methods.
Chondrocytes of fetal rabbit were cultured with nHA/PLGA scaffold in vitro and the cell viability was assessed by MTT assay first.
Cells adhering to nHA/PLGA scaffold were then observed by inverted microscope and scanning electron microscope (SEM).
The cell cycle profile was analyzed by flow cytometry.
Results.
The viability of the chondrocytes on the scaffold was not affected by nHA/PLGA comparing with the control group as it was shown by MTT assay.
Cells on the surface and in the pores of the scaffold increased in a time-dependent manner.
Results obtained from flow cytometry showed that there was no significant difference in cell cycle profiles between the coculture group and control (P>0.05).
Conclusion.
The porous nHA/PLGA composite scaffold is a biocompatible and good kind of scaffold for cartilage tissue engineering.
American Psychological Association (APA)
Chen, Lei& Zhu, Wei-Min& Fei, Zhi-Qiang& Chen, Jie-Lin& Xiong, Jian-Yi& Zhang, Ju-Feng…[et al.]. 2013. The Study on Biocompatibility of Porous nHAPLGA Composite Scaffolds for Tissue Engineering with Rabbit Chondrocytes In Vitro. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004255
Modern Language Association (MLA)
Chen, Lei…[et al.]. The Study on Biocompatibility of Porous nHAPLGA Composite Scaffolds for Tissue Engineering with Rabbit Chondrocytes In Vitro. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1004255
American Medical Association (AMA)
Chen, Lei& Zhu, Wei-Min& Fei, Zhi-Qiang& Chen, Jie-Lin& Xiong, Jian-Yi& Zhang, Ju-Feng…[et al.]. The Study on Biocompatibility of Porous nHAPLGA Composite Scaffolds for Tissue Engineering with Rabbit Chondrocytes In Vitro. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1004255
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004255